ORC1 origin recognition complex subunit 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ORC1
Gene description: origin recognition complex subunit 1
Primary source: SGD:S000004530
Locus tag: YML065W
Gene type: protein coding
RNA name: origin recognition complex subunit 1
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

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See ORC1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (142210..144954)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

the diminished cell-cycle changes in nucleosome occupancy around origins in the orc1-161 mutant are associated with an abnormal global origin usage profile, suggesting that proper establishment of nucleosome occupancy around origins is a critical step for regulation of global origin activities. Our work thus establishes nucleosome occupancy as a novel and key chromatin parameter for proper origin regulation.
Title: Nucleosome occupancy as a novel chromatin parameter for replication origin functions.
Specific ORC1 to DNA replication origins depends on highly conserved basic residues.
Title: Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues.
Data indicate that Cdt1-MCM2-7 complex activates ORC/Cdc6 ATP-hydrolysis to promote helicase loading.
Title: An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.
The functional specialization of Sir3,as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions.
Title: Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.
Coimmunoprecipitation assay confirmed that Cdt1p interacted with Orc6p, as well as with Orc1p and Orc2p.
Title: Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
Activation of the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Assembly of the ORC complex at the origin of replication, organism-specific biosystem (from REACTOME)
Assembly of the ORC complex at the origin of replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
Assembly of the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Association of licensing factors with the pre-replicative complex, organism-specific biosystem (from REACTOME)
Association of licensing factors with the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CDC6 association with the ORC:origin complex, organism-specific biosystem (from REACTOME)
CDC6 association with the ORC:origin complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem (from REACTOME)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle - yeast, organism-specific biosystem (from KEGG)
Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
Cell cycle - yeast, conserved biosystem (from KEGG)
Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
DNA Replication Pre-Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
E2F mediated regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S-Specific Transcription, organism-specific biosystem (from REACTOME)
G1/S-Specific Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
M/G1 Transition, organism-specific biosystem (from REACTOME)
M/G1 Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Meiosis - yeast, organism-specific biosystem (from KEGG)
Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
Meiosis - yeast, conserved biosystem (from KEGG)
Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Origin recognition complex, organism-specific biosystem (from KEGG)
Origin recognition complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
Origin recognition complex, conserved biosystem (from KEGG)
Origin recognition complex, conserved biosystemStructural complex; Genetic information processing; Replication system
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	IEA Inferred from Electronic Annotation more info
ATP binding	IMP Inferred from Mutant Phenotype more info	PubMed
ATPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
DNA binding	IEA Inferred from Electronic Annotation more info
DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA replication	IEA Inferred from Electronic Annotation more info
DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
chromatin silencing at silent mating-type cassette	IDA Inferred from Direct Assay more info	PubMed
chromatin silencing at silent mating-type cassette	IGI Inferred from Genetic Interaction more info	PubMed
mitotic DNA replication checkpoint	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed
pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
DNA replication preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
nuclear chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
nuclear origin of replication recognition complex	IMP Inferred from Mutant Phenotype more info	PubMed
nuclear pre-replicative complex	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: origin recognition complex subunit 1

NP_013646.1

Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

142210..144954

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182424.1 → NP_013646.1 TPA: origin recognition complex subunit 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013646.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54784

Conserved Domains (2) summary

COG1474
Location:426 → 890

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

cd04720
Location:5 → 189

BAH_Orc1p_Yeast; BAH, or Bromo Adjacent Homology domain, as present in Orc1p, which again is part of the Saccharomyces cerevisiae Sir1-origin recognition complex, and as present in Sir3p. The Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a ...