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NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854919, updated on 5-Jun-2017
Gene symbol
NDI1
Gene description
NADH-ubiquinone reductase (H(+)-translocating) NDI1
Primary source
SGD:S000004589
Locus tag
YML120C
Gene type
protein coding
RNA name
NADH-ubiquinone reductase (H(+)-translocating) NDI1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See NDI1 in Map Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (28266..29807, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Rag GTPase GTR1 Neighboring gene hypothetical protein Neighboring gene 3'-5' poly(A) RNA exonuclease

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • NAD/NADP-NADH/NADPH mitochondrial interconversion, organism-specific biosystem (from BIOCYC)
    NAD/NADP-NADH/NADPH mitochondrial interconversion, organism-specific biosystem:NAD and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than any other...
  • NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast), conserved biosystem (from BIOCYC)
    NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast), conserved biosystem|FRAME:NAD| and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than an...
  • aerobic respiration (cytochrome c), organism-specific biosystem (from BIOCYC)
    aerobic respiration (cytochrome c), organism-specific biosystem:NADH and :FADH2 are formed in the glycolytic and TCA cycles. Each of these energy-rich molecules has a pair of electrons with high transfer potential. The transfer of the electrons is performed by a...
  • aerobic respiration (linear view), organism-specific biosystem (from BIOCYC)
    aerobic respiration (linear view), organism-specific biosystemThe electron transport chain is the final step of the respiratory pathway, carried out by several large multisubunit enzyme complexes embedded in the mitochondrial inner membrane. The net effect of...
  • aerobic respiration II (cytochrome c) (yeast), conserved biosystem (from BIOCYC)
    aerobic respiration II (cytochrome c) (yeast), conserved biosystemGeneral Background Like |FRAME: Fermentation fermentation|, respiration is a process by which electrons are passed from an electron donor to a terminal electron acceptor. However, in respiration the...
  • superpathway NAD/NADP - NADH/NADPH interconversion, organism-specific biosystem (from BIOCYC)
    superpathway NAD/NADP - NADH/NADPH interconversion, organism-specific biosystem:NAD and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than any other...
  • superpathway NAD/NADP - NADH/NADPH interconversion (yeast), conserved biosystem (from BIOCYC)
    superpathway NAD/NADP - NADH/NADPH interconversion (yeast), conserved biosystem|FRAME:NAD| and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than an...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
NADH dehydrogenase (ubiquinone) activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NADH oxidation IDA
Inferred from Direct Assay
more info
PubMed 
chronological cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial electron transport, NADH to ubiquinone IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Names
NADH-ubiquinone reductase (H(+)-translocating) NDI1
NP_013586.1
  • NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    28266..29807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182483.1NP_013586.1  TPA: NADH-ubiquinone reductase (H(+)-translocating) NDI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013586.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32340
    Conserved Domains (2) summary
    COG1252
    Location:51509
    Ndh; NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
    cl21454
    Location:258313
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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