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GTR1 Rag GTPase GTR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854918, updated on 2-Nov-2024

Summary

Official Symbol
GTR1
Official Full Name
Rag GTPase GTR1
Primary source
SGD:S000004590
Locus tag
YML121W
See related
AllianceGenome:SGD:S000004590; FungiDB:YML121W; VEuPathDB:YML121W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Involved in several processes, including DNA-templated transcription; positive regulation of TORC1 signaling; and subtelomeric heterochromatin formation. Acts upstream of or within cellular response to oxidative stress. Located in fungal-type vacuole membrane; late endosome membrane; and nucleus. Part of Gtr1-Gtr2 GTPase complex and Ragulator complex. Orthologous to several human genes including RRAGB (Ras related GTP binding B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See GTR1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (26930..27862)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphate transporter PHO84 Neighboring gene uncharacterized protein Neighboring gene NADH-ubiquinone reductase (H(+)-translocating) NDI1 Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to nitrogen starvation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to nitrogen starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphate ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to vacuolar membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase I IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase III IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Gtr1-Gtr2 GTPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of Ragulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Rag GTPase GTR1
NP_013585.1
  • Subunit of TORC1-stimulating GTPase and EGO/GSE complex; subunit of Gtr1-Gtr2 GTPase that activates TORC1 in response to amino acid stimulation; subunit of EGO/GSE vacuolar membrane complex that regulates exit from rapamycin-induced growth arrest and sorting of Gap1p; involved in phosphate transport, telomeric chromatin silencing and oxidative stress response; activated by Iml1p (GAP) subunit of SEACIT complex; targeted to vacuole via AP-3 pathway; similar to human RagA and RagB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    26930..27862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182484.1NP_013585.1  TPA: Rag GTPase GTR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013585.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0G3, Q00582
    UniProtKB/TrEMBL
    A6ZLU3, B3LLD8, B5VP09, C7GVA3, C8ZE81, G2WJT5, N1P024
    Conserved Domains (1) summary
    cd11384
    Location:8304
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B