MSC1 double-strand break repair enhancer MSC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MSC1
Official Full Name: double-strand break repair enhancer MSC1
Primary source: SGD:S000004597
Locus tag: YML128C
See related: AllianceGenome:SGD:S000004597; FungiDB:YML128C; VEuPathDB:YML128C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in reciprocal meiotic recombination. Acts upstream of or within protein localization to site of double-strand break. Located in mitochondrion. Is active in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to site of double-strand break	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed

NP_013578.1

Nuclear envelope protein involved in DSB repair during late mitosis; forms nuclear envelope patches associated with Rad52p-containing DNA repair foci, and accelerates homologous recombination downstream of DNA end resection; mutant is defective in directing meiotic recombination events to homologous chromatids; upregulated after DNA damage in late mitosis; null mutant is hypersensitive to DSBs; non-tagged protein is detected in highly purified mitochondria and is phosphorylated

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The following sections contain reference sequences that belong to a specific genome build. Explain