U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COG8 Golgi transport complex subunit COG8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854904, updated on 30-Jul-2025
Official Symbol
COG8
Official Full Name
Golgi transport complex subunit COG8
Primary source
SGD:S000004536
Locus tag
YML071C
See related
AllianceGenome:SGD:S000004536; FungiDB:YML071C; VEuPathDB:YML071C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DOR1
Summary
Involved in cytoplasm to vacuole targeting by the Cvt pathway and intra-Golgi vesicle-mediated transport. Located in cytosol. Part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIh. Orthologous to human COG8 (component of oligomeric golgi complex 8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See COG8 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (129749..131572, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein eL6 RPL6A Neighboring gene Tcb3p Neighboring gene tRNA-Arg Neighboring gene dihydroxyacetone kinase

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking. Wang IH, et al. Traffic, 2017 Sep. PMID 28627726
  2. Molecular organization of the COG vesicle tethering complex. Lees JA, et al. Nat Struct Mol Biol, 2010 Nov. PMID 20972446, Free PMC Article
  3. Molecular architecture of the complete COG tethering complex. Ha JY, et al. Nat Struct Mol Biol, 2016 Aug. PMID 27428773, Free PMC Article
  4. Detailed Analysis of the Interaction of Yeast COG Complex. Ishii M, et al. Cell Struct Funct, 2018 Jul 19. PMID 29899178, Free PMC Article
  5. Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. Fotso P, et al. J Biol Chem, 2005 Jul 29. PMID 15932880

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atg9 accumulates at the late Golgi in arl3cog8Delta and arl1cog8Delta cells under normal growth conditions but not under starvation conditions
    Title: The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasm to vacuole targeting by the Cvt pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, vesicle recycling within Golgi NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of Golgi transport complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Golgi transport complex subunit COG8
NP_013640.1
  • Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    129749..131572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182430.1 → NP_013640.1  TPA: Golgi transport complex subunit COG8

    See identical proteins and their annotated locations for NP_013640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZA2, Q03641, Q04632
    UniProtKB/TrEMBL
    G2WJY4
    Conserved Domains (2) summary
    PTZ00341
    Location:244 → 517
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam04124
    Location:28 → 375
    Dor1; Dor1-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04632.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools