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HMG1 hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854900, updated on 9-Jun-2024

Summary

Gene symbol
HMG1
Gene description
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
Primary source
FungiDB:YML075C
Locus tag
YML075C
See related
SGD:S000004540; AllianceGenome:SGD:S000004540; VEuPathDB:YML075C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and nuclear envelope. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HMG1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (115734..118898, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene TRAPP subunit BET5 Neighboring gene War1p Neighboring gene peptidylprolyl isomerase FPR3 Neighboring gene ribosomal 60S subunit protein L6A

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear periphery HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
NP_013636.1
  • HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; expressed almost exclusively on the peri-nuclear side of the ER; human homolog HMGCR can complement yeast hmg1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    115734..118898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182434.1NP_013636.1  TPA: hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013636.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0K8, P12683
    UniProtKB/TrEMBL
    A0A8H4BX21, A6ZLZ0, B3LLI1, G2WJY0, N1P0U1
    Conserved Domains (3) summary
    TIGR00533
    Location:6161025
    HMG_CoA_R_NADP; 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP)
    TIGR00920
    Location:1891025
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    pfam13323
    Location:10161
    HPIH; N-terminal domain with HPIH motif