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HMG1 hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854900, updated on 3-Jun-2026
Official Symbol
HMG1
Official Full Name
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
Primary source
SGD:S000004540
Locus tag
YML075C
See related
AllianceGenome:SGD:S000004540; FungiDB:YML075C; VEuPathDB:YML075C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and nuclear envelope. Is active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See HMG1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (115734..118898, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene TRAPP subunit BET5 Neighboring gene War1p Neighboring gene peptidylprolyl isomerase FPR3 Neighboring gene 60S ribosomal protein eL6 RPL6A

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Enhancement of β-carotene production by over-expression of HMG-CoA reductase coupled with addition of ergosterol biosynthesis inhibitors in recombinant Saccharomyces cerevisiae. Yan GL, et al. Curr Microbiol, 2012 Feb. PMID 22086347
  2. High-level recombinant production of squalene using selected Saccharomyces cerevisiae strains. Han JY, et al. J Ind Microbiol Biotechnol, 2018 Apr. PMID 29396745
  3. Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. Donald KA, et al. Appl Environ Microbiol, 1997 Sep. PMID 9292983, Free PMC Article
  4. Location and regulation of early enzymes of sterol biosynthesis in yeast. Trocha PJ, et al. Arch Biochem Biophys, 1976 May. PMID 7207
  5. Metabolic engineering of Saccharomyces cerevisiae for linalool production. Amiri P, et al. Biotechnol Lett, 2016 Mar. PMID 26614300

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. although related, Hmg2p- and Hmg1p-induced ER remodeling are mechanistically distinct
    Title: Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity RCA
inferred from Reviewed Computational Analysis
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ergosterol biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
Component Evidence Code Pubs
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope EXP
Inferred from Experiment
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear periphery HDA PubMed 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
NP_013636.1
  • HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; expressed almost exclusively on the peri-nuclear side of the ER; human homolog HMGCR can complement yeast hmg1 mutant

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    115734..118898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182434.1 → NP_013636.1  hydroxymethylglutaryl-CoA reductase (NADPH) HMG1

    See identical proteins and their annotated locations for NP_013636.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0K8, P12683
    UniProtKB/TrEMBL
    A6ZLZ0, B3LLI1, G2WJY0, N1P0U1
    Conserved Domains (3) summary
    TIGR00533
    Location:616 → 1025
    HMG_CoA_R_NADP; 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP)
    TIGR00920
    Location:189 → 1025
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    pfam13323
    Location:10 → 161
    HPIH; N-terminal domain with HPIH motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12683.1

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