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LGR5 leucine rich repeat containing G protein-coupled receptor 5 [ Homo sapiens (human) ]

Gene ID: 8549, updated on 23-Nov-2021

Summary

Official Symbol
LGR5provided by HGNC
Official Full Name
leucine rich repeat containing G protein-coupled receptor 5provided by HGNC
Primary source
HGNC:HGNC:4504
See related
Ensembl:ENSG00000139292 MIM:606667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEX; HG38; GPR49; GPR67; GRP49
Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in placenta (RPKM 11.9), small intestine (RPKM 3.2) and 8 other tissues See more
Orthologs
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Genomic context

See LGR5 in Genome Data Viewer
Location:
12q21.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (71439798..71586310)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (71833578..71980090)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369831 Neighboring gene uncharacterized LOC105369832 Neighboring gene uncharacterized LOC105369833 Neighboring gene zinc finger C3H1-type containing Neighboring gene uncharacterized LOC107984529 Neighboring gene THAP domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
GeneReviews: Not available
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117008

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 5
Names
G-protein coupled receptor 49
G-protein coupled receptor 67
G-protein coupled receptor HG38
orphan G protein-coupled receptor HG38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277226.2NP_001264155.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001264155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC078860, BC096325, CA412916, DR003044
    Consensus CDS
    CCDS61194.1
    UniProtKB/Swiss-Prot
    O75473
    Related
    ENSP00000441035.2, ENST00000540815.2
    Conserved Domains (7) summary
    smart00013
    Location:3370
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:71360
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:306329
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6891
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:351430
    LRR_8; Leucine rich repeat
    cd14964
    Location:536560
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:534807
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001277227.2NP_001264156.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001264156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC078860, CA412916, DR003044, FN820440
    Consensus CDS
    CCDS61195.1
    UniProtKB/Swiss-Prot
    O75473
    Related
    ENSP00000443033.1, ENST00000536515.5
    Conserved Domains (6) summary
    smart00013
    Location:3370
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:71312
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:4767
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6891
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:486759
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam13855
    Location:303382
    LRR_8; Leucine rich repeat
  3. NM_003667.4NP_003658.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC078860, AF062006, CA412916, DR003044
    Consensus CDS
    CCDS9000.1
    UniProtKB/Swiss-Prot
    O75473
    UniProtKB/TrEMBL
    A0A0A8K8C7
    Related
    ENSP00000266674.4, ENST00000266674.10
    Conserved Domains (5) summary
    smart00013
    Location:3370
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:71426
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:307353
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6891
    LRR_RI; leucine-rich repeat [structural motif]
    cd15363
    Location:558831
    7tmA_LGR5; leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_110596.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 3' structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC078860, AK075399, AK294985, BQ774570, DA811892, DR003044, H88004
    Related
    ENST00000550851.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    71439798..71586310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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