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Twist1 twist family bHLH transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85489, updated on 3-Jun-2018
Official Symbol
Twist1provided by RGD
Official Full Name
twist family bHLH transcription factor 1provided by RGD
Primary source
RGD:621455
See related
Ensembl:ENSRNOG00000011101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Twist
Summary
beta helix loop helix transcription factor [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 31.6), Heart (RPKM 27.2) and 8 other tissues See more
Orthologs
See Twist1 in Genome Data Viewer
Location:
6q16
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (53401241..53403235)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (63023523..63025517)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene similar to 40S ribosomal protein S20 Neighboring gene Fer3-like bHLH transcription factor Neighboring gene similar to developmental pluripotency associated 4 isoform 1 Neighboring gene histone deacetylase 9 Neighboring gene uncharacterized LOC108351350

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
E-box binding IEA
Inferred from Electronic Annotation
more info
 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aortic valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
bone development IEP
Inferred from Expression Pattern
more info
PubMed 
cardiac neural crest cell development involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell proliferation involved in heart valve development IEA
Inferred from Electronic Annotation
more info
 
cell proliferation involved in heart valve development ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cranial suture morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cranial suture morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic camera-type eye formation IEA
Inferred from Electronic Annotation
more info
 
embryonic camera-type eye formation ISO
Inferred from Sequence Orthology
more info
 
embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic cranial skeleton morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
eyelid development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
eyelid development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
mitral valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mitral valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
negative regulation of double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
negative regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of histone phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of molecular function ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative phosphorylation uncoupler activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative phosphorylation uncoupler activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peroxisome proliferator activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neural tube closure ISO
Inferred from Sequence Orthology
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
odontogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
ossification ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-templated transcription, initiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell motility IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotactic protein-1 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
roof of mouth development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
twist-related protein 1
Names
twist basic helix-loop-helix transcription factor 1
twist gene homolog 1
twist homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053530.2NP_445982.1  twist-related protein 1

    See identical proteins and their annotated locations for NP_445982.1

    Status: VALIDATED

    Source sequence(s)
    AJ131845, BF420349, BQ206289
    UniProtKB/TrEMBL
    Q9EPJ1
    Related
    ENSRNOP00000014763.3, ENSRNOT00000014763.6
    Conserved Domains (1) summary
    pfam00010
    Location:110160
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    53401241..53403235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    49841416..49843227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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