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TUB1 alpha-tubulin TUB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854889, updated on 5-Sep-2021

Summary

Gene symbol
TUB1
Gene description
alpha-tubulin TUB1
Primary source
SGD:S000004550
Locus tag
YML085C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See TUB1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (97941..99400, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene cytochrome-b5 reductase Neighboring gene D-arabinono-1,4-lactone oxidase Neighboring gene uncharacterized protein Neighboring gene putative cystathionine gamma-synthase

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the TUB1 gene: The TUB1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear migration along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear migration by microtubule mediated pushing forces IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic microtubule IC
Inferred by Curator
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore microtubule IC
Inferred by Curator
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear microtubule IC
Inferred by Curator
more info
PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in polar microtubule IC
Inferred by Curator
more info
PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of tubulin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of tubulin complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
alpha-tubulin TUB1
NP_013625.1
  • Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    97941..99400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182444.1NP_013625.1  TPA: alpha-tubulin TUB1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013625.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09733
    Conserved Domains (1) summary
    cd02186
    Location:2436
    alpha_tubulin; The alpha-tubulin family
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