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TUB1 alpha-tubulin TUB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854889, updated on 13-Apr-2024

Summary

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Gene symbol
TUB1
Gene description
alpha-tubulin TUB1
Primary source
SGD:S000004550
Locus tag
YML085C
See related
AllianceGenome:SGD:S000004550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in homologous chromosome segregation; mitotic sister chromatid segregation; and nuclear migration along microtubule. Located in nuclear periphery. Part of tubulin complex. Human ortholog(s) of this gene implicated in several diseases, including Fanconi renotubular syndrome 3; amyotrophic lateral sclerosis type 22; keratoconus; lissencephaly (multiple); and visual epilepsy. Orthologous to several human genes including TUBA1A (tubulin alpha 1a); TUBA1B (tubulin alpha 1b); and TUBA1C (tubulin alpha 1c). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (97941..99400, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene cytochrome-b5 reductase Neighboring gene D-arabinono-1,4-lactone oxidase Neighboring gene uncharacterized protein Neighboring gene putative cystathionine gamma-synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy. Pearson CG, et al. Mol Biol Cell, 2006 Sep. PMID 16807354, Free PMC Article
  2. Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin. Badin-Larçon AC, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15031428, Free PMC Article
  3. Single site alpha-tubulin mutation affects astral microtubules and nuclear positioning during anaphase in Saccharomyces cerevisiae: possible role for palmitoylation of alpha-tubulin. Caron JM, et al. Mol Biol Cell, 2001 Sep. PMID 11553707, Free PMC Article
  4. Tubulin and FtsZ form a distinct family of GTPases. Nogales E, et al. Nat Struct Biol, 1998 Jun. PMID 9628483
  5. Microtubular dynamics of Saccharomyces cerevisiae temperature-sensitive secretory mutants: the sec 1 product and polymerization of microtubules. Briestanská J. Folia Biol (Praha), 1990. PMID 2279585

See all (176) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function.
    Title: Modeling a disease-correlated tubulin mutation in budding yeast reveals insight into MAP-mediated dynein function.
  2. An unexpected antagonism has been found between the tubulin-binding Stu2 domains (TOGs) and the lattice-binding basic region: lattice binding by the basic region is weak when at least two TOGs engage tubulins, strong when TOGs are empty.
    Title: Design principles of a microtubule polymerase.
  3. The polymerization blocked forms of alphabeta-tubulin give a lethal phenotype when expressed in cells.
    Title: Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.
  4. Disruption of microtubules by a temperature-sensitive allele of TUB1 stimulates P-body formation.
    Title: Microtubule disruption stimulates P-body formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear migration along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear migration by microtubule mediated pushing forces IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tubulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of tubulin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
alpha-tubulin TUB1
NP_013625.1
  • Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    97941..99400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182444.1 → NP_013625.1  TPA: alpha-tubulin TUB1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013625.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0J8, P09733
    UniProtKB/TrEMBL
    A6ZLY0, B3LLH1, C7GW20, C8ZEB9, G2WJX0, N1NZ92
    Conserved Domains (1) summary
    cd02186
    Location:2 → 436
    alpha_tubulin; The alpha-tubulin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4FFB_A.1
5W3F_A.1
5W3H_A.1
5W3J_A.1
P09733.2

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