ALO1 D-arabinono-1,4-lactone oxidase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ALO1
Official Full Name: D-arabinono-1,4-lactone oxidase
Primary source: SGD:S000004551
Locus tag: YML086C
See related: AllianceGenome:SGD:S000004551; FungiDB:YML086C; VEuPathDB:YML086C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables D-arabinono-1,4-lactone oxidase activity and myosin V binding activity. Involved in cellular response to oxidative stress and dehydro-D-arabinono-1,4-lactone biosynthetic process. Acts upstream of or within mitochondrion inheritance. Located in cytoplasmic side of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables D-arabinono-1,4-lactone oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-arabinono-1,4-lactone oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables D-arabinono-1,4-lactone oxidase activity	IEA Inferred from Electronic Annotation more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables myosin V binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dehydro-D-arabinono-1,4-lactone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion inheritance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic side of mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_013624.1

D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; putative adaptor protein that interacts with the cargo-binding domain of Myo2p and has a role in mitochondrial inheritance, especially under conditions of oxidative stress; localizes to the mitochondrial outer membrane; null mutant shows improved noncanonical amino acid incorporation efficiency in response to the amber (TAG) stop codon