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PRE8 proteasome core particle subunit alpha 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854882, updated on 18-Sep-2024

Summary

Official Symbol
PRE8
Official Full Name
proteasome core particle subunit alpha 2
Primary source
SGD:S000004557
Locus tag
YML092C
See related
AllianceGenome:SGD:S000004557; FungiDB:YML092C; VEuPathDB:YML092C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA2 (proteasome 20S subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PRE8 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (85987..86739, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Gim5p Neighboring gene Utp14p Neighboring gene ribonuclease P Neighboring gene ncRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome core particle subunit alpha 2
NP_013618.1
  • Alpha 2 subunit of the 20S proteasome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    85987..86739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182451.1NP_013618.1  TPA: proteasome core particle subunit alpha 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013618.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0J3, P23639
    UniProtKB/TrEMBL
    A6ZLX5, B3LLG6, B5VP40, C7GV75, C8ZEB3, G2WJW5, N1P0N9
    Conserved Domains (1) summary
    cd03750
    Location:5247
    proteasome_alpha_type_2; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...