URA5 orotate phosphoribosyltransferase URA5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: URA5
Official Full Name: orotate phosphoribosyltransferase URA5
Primary source: SGD:S000004574
Locus tag: YML106W
See related: AllianceGenome:SGD:S000004574; FungiDB:YML106W; VEuPathDB:YML106W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PYR5
Summary: Enables orotate phosphoribosyltransferase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleoside biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See URA5 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (56773..57453)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables orotate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotate phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables orotate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotate phosphoribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables orotate phosphoribosyltransferase activity	RCA inferred from Reviewed Computational Analysis more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' UMP biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in nucleotide biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in pyrimidine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine ribonucleoside biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine ribonucleoside biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine ribonucleoside biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine ribonucleoside biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine ribonucleotide biosynthetic process	RCA inferred from Reviewed Computational Analysis more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: orotate phosphoribosyltransferase URA5

NP_013601.1

EC 2.4.2.10

Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

56773..57453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182468.1 → NP_013601.1 orotate phosphoribosyltransferase URA5

See identical proteins and their annotated locations for NP_013601.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0H8, P13298

UniProtKB/TrEMBL

B3LLF3

Conserved Domains (1) summary

TIGR00336
Location:14 → 199

pyrE; orotate phosphoribosyltransferase