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FLO11 Flo11p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854836, updated on 23-Apr-2026
Official Symbol
FLO11
Official Full Name
Flo11p
Primary source
SGD:S000001458
Locus tag
YIR019C
See related
AllianceGenome:SGD:S000001458; FungiDB:YIR019C; VEuPathDB:YIR019C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MUC1; STA4
Summary
Involved in several processes, including invasive growth in response to glucose limitation; pseudohyphal growth; and single-species biofilm formation. Located in cellular bud neck; extracellular region; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See FLO11 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (389572..393675, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Yap5p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The N-terminal domain of the Flo11 protein from Saccharomyces cerevisiae is an adhesin without mannose-binding activity. Goossens KV, et al. FEMS Yeast Res, 2012 Feb. PMID 22129043
  2. Controlled expression of the dominant flocculation genes FLO1, FLO5, and FLO11 in Saccharomyces cerevisiae. Govender P, et al. Appl Environ Microbiol, 2008 Oct. PMID 18708514, Free PMC Article
  3. Coding repeat instability in the FLO11 gene of Saccharomyces yeasts. Fidalgo M, et al. Yeast, 2008 Dec. PMID 19160455
  4. FLO11 gene length and transcriptional level affect biofilm-forming ability of wild flor strains of Saccharomyces cerevisiae. Zara G, et al. Microbiology (Reading), 2009 Dec. PMID 19729408
  5. Epigenetic and conventional regulation is distributed among activators of FLO11 allowing tuning of population-level heterogeneity in its expression. Octavio LM, et al. PLoS Genet, 2009 Oct. PMID 19798446, Free PMC Article

See all (172) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variation in pH gradients and FLO11 expression in mat biofilms from environmental isolates of the yeast Saccharomyces cerevisiae.
    Title: Variation in pH gradients and FLO11 expression in mat biofilms from environmental isolates of the yeast Saccharomyces cerevisiae.
  2. The dual role of amyloid-beta-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae.
    Title: The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae.
  3. Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.
    Title: Kin discrimination in social yeast is mediated by cell surface receptors of the Flo11 adhesin family.
  4. Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops.
    Title: Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops.
  5. Study provides clear evidence of the functions of the Tup1p and Cyc8p regulators in biofilm colony formation. Cyc8p itself is a repressor of FLO11 gene expression and of the formation of the structured architecture of colony biofilms, whereas Tup1p counteracts Cyc8p, being a positive regulator of FLO11 expression and colony complexity.
    Title: Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms.
  6. by deleting many of the known transcriptional activators of invasion, as well as the gene encoding the cell surface protein Flo11 from five relevant segregants and showing that these individuals differ in the genes they require for invasion
    Title: Regulatory Rewiring in a Cross Causes Extensive Genetic Heterogeneity.
  7. IRA2 mutation reveals the phenotypic effects of the cryptic variants by disrupting the transcriptional silencing of one or more genes that contribute to the trait.We also show that this ability to disrupt FLO11 repression is not unique to IRA2
    Title: Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions.
  8. Interactions by the fungal Flo11 adhesin depend on a fibronectin type III-like adhesin domain girdled by aromatic bands.
    Title: Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-like Adhesin Domain Girdled by Aromatic Bands.
  9. Gcn5 plays an important role in the regulatory network of FLO11 expression via Gcn4 by downregulating ICR1 expression, which derepresses FLO11 for promoting pseudohyphal development
    Title: The Histone Acetyltransferase Gcn5 Regulates ncRNA-ICR1 and FLO11 Expression during Pseudohyphal Development in Saccharomyces cerevisiae.
  10. Flo11 downregulation causes filamentous and invasive growth of rho mutants.
    Title: Dysfunctional mitochondria modulate cAMP-PKA signaling and filamentous and invasive growth of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction See all GeneRIFs (35)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion involved in single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell self recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in filamentous growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in flocculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single-species surface biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Flo11p
NP_012284.3
  • GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; QTL that controls chronological life span; carries intragenic tandem repeats that are expanded in different strains; required for formation of fibrous interconnections between cells; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    389572..393675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179541.3 → NP_012284.3  Flo11p

    See identical proteins and their annotated locations for NP_012284.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVV0, P08068, P08640
    UniProtKB/TrEMBL
    A0A8H4BZA4, Q6LCS8
    Conserved Domains (2) summary
    pfam05109
    Location:1071 → 1322
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam10182
    Location:43 → 193
    Flo11; Flo11 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08640.2

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