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EGH1 hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854824, updated on 3-Jun-2026
Official Symbol
EGH1
Official Full Name
hydrolase
Primary source
SGD:S000001446
Locus tag
YIR007W
See related
AllianceGenome:SGD:S000001446; FungiDB:YIR007W; VEuPathDB:YIR007W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables steryl-beta-glucosidase activity. Involved in ergosteryl 3-beta-D-glucoside catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See EGH1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (370704..372998)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene actin cytoskeleton-regulatory complex protein PAN1 Neighboring gene tRNA-Glu Neighboring gene DNA primase subunit PRI1 Neighboring gene U2 snRNP complex subunit MSL1

Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae. Watanabe T, et al. Glycobiology, 2015 Oct. PMID 26116408
  2. Identification of a Saccharomyces cerevisiae glucosidase that hydrolyzes flavonoid glucosides. Schmidt S, et al. Appl Environ Microbiol, 2011 Mar. PMID 21216897, Free PMC Article
  3. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870
  4. Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. Franzosa EA, et al. PLoS One, 2011. PMID 22140548, Free PMC Article
  5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Egh1 is an ergosteryl-beta-glucosidase that is functionally involved in the ergosteryl-beta-glucoside catabolic pathway and vacuole formation in S. cerevisiae.
    Title: Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables steryl-beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steryl-beta-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate derivative catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ergosteryl 3-beta-D-glucoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosteryl 3-beta-D-glucoside catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
located_in vacuolar membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
hydrolase
NP_012272.3
  • Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    370704..372998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179529.3 → NP_012272.3  hydrolase

    See identical proteins and their annotated locations for NP_012272.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVT7, P40566
    UniProtKB/TrEMBL
    A6ZVS6, N1P2A5
    Conserved Domains (2) summary
    pfam18564
    Location:654 → 738
    Glyco_hydro_5_C; Glycoside hydrolase family 5 C-terminal domain
    cl23725
    Location:77 → 133
    Glyco_hydro; Glycosyl hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40566.1

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