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TSLP thymic stromal lymphopoietin [ Homo sapiens (human) ]

Gene ID: 85480, updated on 17-Jun-2019

Summary

Official Symbol
TSLPprovided by HGNC
Official Full Name
thymic stromal lymphopoietinprovided by HGNC
Primary source
HGNC:HGNC:30743
See related
Ensembl:ENSG00000145777 MIM:607003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Broad expression in gall bladder (RPKM 3.6), liver (RPKM 3.0) and 15 other tissues See more
Orthologs

Genomic context

See TSLP in Genome Data Viewer
Location:
5q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (111070080..111078026)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (110405778..110413722)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene integrin alpha FG-GAP repeat containing 2 pseudogene Neighboring gene uncharacterized LOC105379121 Neighboring gene WD repeat domain 36 Neighboring gene proline rich nuclear receptor coactivator 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
NHGRI GWA Catalog
Common variants at 5q22 associate with pediatric eosinophilic esophagitis.
NHGRI GWA Catalog
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
NHGRI GWA Catalog
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
NHGRI GWA Catalog
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
NHGRI GWA Catalog
GWAS identifies four novel eosinophilic esophagitis loci.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
NHGRI GWA Catalog
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Development and heterogeneity of the ILC family, organism-specific biosystem (from WikiPathways)
    Development and heterogeneity of the ILC family, organism-specific biosystemDevelopment and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription f...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem
    Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-7 receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine (C-C motif) ligand 1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of granulocyte colony-stimulating factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-13 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-5 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thymic stromal lymphopoietin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033035.5NP_149024.1  thymic stromal lymphopoietin isoform 1 precursor

    See identical proteins and their annotated locations for NP_149024.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1, also known as lfTSLP). This isoform is found in much lower abundance compared to the shorter isoform sfTSLP (PMID:24850429) and is known to stimulate allergic inflammation in diseases such as asthma and COPD.
    Source sequence(s)
    AC008572, AL833421, AY037115
    Consensus CDS
    CCDS4101.1
    UniProtKB/Swiss-Prot
    Q969D9
    Related
    ENSP00000339804.3, ENST00000344895.4
    Conserved Domains (1) summary
    pfam15216
    Location:29153
    TSLP; Thymic stromal lymphopoietin
  2. NM_138551.5NP_612561.2  thymic stromal lymphopoietin isoform 2

    See identical proteins and their annotated locations for NP_612561.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as sfTSLP) lacks two 5' exons but contains an alternate 5' exon, differs in the 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. This is the predominant isoform, and it exhibits a much stronger antimicrobial activity compared to the longer isoform lfTSLP (PMID:24850429).
    Source sequence(s)
    AC008572, AL833421, BU571002
    UniProtKB/Swiss-Prot
    Q969D9
    Related
    ENSP00000427827.1, ENST00000379706.4
    Conserved Domains (1) summary
    pfam15216
    Location:157
    TSLP; Thymic stromal lymphopoietin

RNA

  1. NR_045089.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008572, AL833421, BC040592

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    111070080..111078026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543698.1XP_011542000.1  thymic stromal lymphopoietin isoform X1

    See identical proteins and their annotated locations for XP_011542000.1

    UniProtKB/Swiss-Prot
    Q969D9
    Conserved Domains (1) summary
    pfam15216
    Location:157
    TSLP; Thymic stromal lymphopoietin
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