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BAR1 aspartyl protease BAR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854797, updated on 15-Mar-2026
Official Symbol
BAR1
Official Full Name
aspartyl protease BAR1
Primary source
SGD:S000001277
Locus tag
YIL015W
See related
AllianceGenome:SGD:S000001277; FungiDB:YIL015W; VEuPathDB:YIL015W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SST1
Summary
Enables aspartic-type endopeptidase activity. Involved in cellular response to pheromone; conjugation with cellular fusion; and peptide catabolic process. Located in extracellular region and fungal-type cell wall. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See BAR1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (322342..324105)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene glucose-induced degradation complex subunit VID28 Neighboring gene Snl1p Neighboring gene tRNA-Asp Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Recovery of S. cerevisiae a cells from G1 arrest by alpha factor pheromone requires endopeptidase action. Ciejek E, et al. Cell, 1979 Nov. PMID 391400
  2. Properties of Barrier, a novel Saccharomyces cerevisiae acid protease. Nath R. Biochimie, 1993. PMID 8364097
  3. Periplasmic Bar1 protease of Saccharomyces cerevisiae is active before reaching its extracellular destination. Ballensiefen W, et al. Eur J Biochem, 1997 Jul 1. PMID 9249020
  4. Somatostatin receptors and regulation of cell proliferation. Bousquet C, et al. Dig Liver Dis, 2004 Feb. PMID 15077905
  5. Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Chan RK, et al. Mol Cell Biol, 1982 Jan. PMID 7050665, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the effect of sequence-directed nucleosome disruption on cell-type-specific repression of BAR1 by alpha2/Mcm1 in the yeast genome.
    Title: Effect of sequence-directed nucleosome disruption on cell-type-specific repression by alpha2/Mcm1 in the yeast genome.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to pheromone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in conjugation with cellular fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in fungal-type cell wall IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
aspartyl protease BAR1
NP_012249.1
  • Aspartyl protease secreted to periplasmic space of mating type a cell; helps cells monitor availability of mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    322342..324105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179365.1 → NP_012249.1  aspartyl protease BAR1

    See identical proteins and their annotated locations for NP_012249.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVR4, P12630
    UniProtKB/TrEMBL
    B3LTM3, B5VKS5, C7GSF7, C8ZAN5, N1P965
    Conserved Domains (1) summary
    cd05474
    Location:43 → 395
    SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12630.1

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