HIS6 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: HIS6
Official Full Name: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6
Primary source: SGD:S000001282
Locus tag: YIL020C
See related: AllianceGenome:SGD:S000001282; FungiDB:YIL020C; VEuPathDB:YIL020C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity. Involved in L-histidine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See HIS6 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (314035..314820, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

X-ray structure at a resolution of 1.30 A. This model enables us to identify catalytic residues and to propose a reaction mechanism where two aspartates act as acid/base catalysts
Title: Crystal structure of the yeast His6 enzyme suggests a reaction mechanism.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	IEA Inferred from Electronic Annotation more info
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-histidine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in L-histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6

NP_012244.3

EC 5.3.1.16

Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

314035..314820 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179370.3 → NP_012244.3 TPA: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6

See identical proteins and their annotated locations for NP_012244.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVQ9, P40545, Q6Q5P5

UniProtKB/TrEMBL

A0A0L8VNZ0, B3LTM8, B5VKS1, C7GPW8, C8ZAN0, G2WGC4, N1P0N3

Conserved Domains (1) summary

TIGR02129
Location:2 → 258

hisA_euk; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic type