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YKE4 Zn(2+) transporter YKE4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854789, updated on 3-May-2025
Official Symbol
YKE4
Official Full Name
Zn(2+) transporter YKE4
Primary source
SGD:S000001285
Locus tag
YIL023C
See related
AllianceGenome:SGD:S000001285; FungiDB:YIL023C; VEuPathDB:YIL023C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables zinc ion transmembrane transporter activity. Involved in zinc ion transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Ehlers-Danlos syndrome spondylodysplastic type 3; and agammaglobulinemia 9. Orthologous to several human genes including SLC39A13 (solute carrier family 39 member 13). [provided by Alliance of Genome Resources, May 2025]
Orthologs
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See YKE4 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (309386..310426, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene cohesin subunit IRR1 Neighboring gene Atg45p Neighboring gene protein translocase subunit TIM44 Neighboring gene DNA-directed RNA polymerase II core subunit RPB3

Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast. Pupo A, et al. Biol Trace Elem Res, 2020 May. PMID 31392542, Free PMC Article
  2. YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae. Kumánovics A, et al. J Biol Chem, 2006 Aug 11. PMID 16760462
  3. TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays. Kim C, et al. BMC Bioinformatics, 2007 Apr 18. PMID 17442117, Free PMC Article
  4. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870
  5. Exploring genetic suppression interactions on a global scale. van Leeuwen J, et al. Science, 2016 Nov 4. PMID 27811238, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yke4p balances zinc levels between the cytosol and the secretory pathway
    Title: YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metal ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Zn(2+) transporter YKE4
NP_012241.1
  • Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    309386..310426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179373.1 → NP_012241.1  TPA: Zn(2+) transporter YKE4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012241.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVQ6, P40544
    UniProtKB/TrEMBL
    G2WGC1, N1P277
    Conserved Domains (1) summary
    pfam02535
    Location:63 → 344
    Zip; ZIP Zinc transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40544.1

Gene LinkOut

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