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EMC5 Emc5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854785, updated on 8-Mar-2025

Summary

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Official Symbol
EMC5
Official Full Name
Emc5p
Primary source
SGD:S000001289
Locus tag
YIL027C
See related
AllianceGenome:SGD:S000001289; FungiDB:YIL027C; VEuPathDB:YIL027C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KRE27
Summary
Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum. Part of EMC complex. [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See EMC5 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (303679..304104, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene Ema17p Neighboring gene cohesin subunit IRR1 Neighboring gene Atg45p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
  2. A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin. Pagé N, et al. Genetics, 2003 Mar. PMID 12663529, Free PMC Article
  3. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
  4. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
  5. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Bircham PW, et al. Mol Biosyst, 2011 Sep. PMID 21731954

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein folding in endoplasmic reticulum HGI PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Emc5p
NP_012237.1
  • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    303679..304104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179377.1 → NP_012237.1  TPA: Emc5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVQ3, P40540
    UniProtKB/TrEMBL
    A6ZVP1, B3LTN4, C7GPX4, C8ZAM1, G2WGB8, N1P459
    Conserved Domains (1) summary
    pfam10270
    Location:9 → 129
    MMgT; Membrane magnesium transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40540.1

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