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AGE2 GTPase-activating protein AGE2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854767, updated on 24-Jan-2026
Official Symbol
AGE2
Official Full Name
GTPase-activating protein AGE2
Primary source
SGD:S000001306
Locus tag
YIL044C
See related
AllianceGenome:SGD:S000001306; FungiDB:YIL044C; VEuPathDB:YIL044C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SAT2
Summary
Enables GTPase activator activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in cytosol. Orthologous to several human genes including SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See AGE2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (272950..273846, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 Neighboring gene putative protein phosphatase regulator PIG2 Neighboring gene cytochrome-b5 reductase Neighboring gene protein kinase PKP1

Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Arf-GAP Age2 localizes to the late-Golgi via a conserved amphipathic helix. Manzer KM, et al. Mol Biol Cell, 2023 Nov 1. PMID 37672345, Free PMC Article
  2. The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network. Poon PP, et al. J Cell Biol, 2001 Dec 24. PMID 11756474, Free PMC Article
  3. Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Yanagisawa LL, et al. Mol Biol Cell, 2002 Jul. PMID 12134061, Free PMC Article
  4. A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae. Zhang CJ, et al. J Biol Chem, 1998 Jul 31. PMID 9677411
  5. The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport. Benjamin JJ, et al. J Biol Chem, 2011 Feb 18. PMID 21135091, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering.
    Title: AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
Preferred Names
GTPase-activating protein AGE2
NP_012220.3
  • ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    272950..273846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179394.3 → NP_012220.3  GTPase-activating protein AGE2

    See identical proteins and their annotated locations for NP_012220.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVN8, P40529
    UniProtKB/TrEMBL
    G2WGA2, N1P263
    Conserved Domains (1) summary
    COG5347
    Location:1 → 298
    COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40529.1

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