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EFM4 Efm4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854746, updated on 5-Jul-2025
Official Symbol
EFM4
Official Full Name
Efm4p
Primary source
SGD:S000001326
Locus tag
YIL064W
See related
AllianceGenome:SGD:S000001326; FungiDB:YIL064W; VEuPathDB:YIL064W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SEE1
Summary
Enables protein-lysine N-methyltransferase activity. Predicted to be involved in methylation and vesicle-mediated transport. Is active in cytoplasm. Orthologous to human EEF1AKMT2 (EEF1A lysine methyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See EFM4 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (242027..242716)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ribonucleotide-diphosphate reductase subunit RNR3 Neighboring gene Fis1p Neighboring gene Yrb2p Neighboring gene Arc15p

Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Absence of See1p, a widely conserved Saccharomyces cerevisiae protein, confers both deficient heterologous protein production and endocytosis. Martín-Granados C, et al. Yeast, 2008 Dec. PMID 19160456
  2. Methylation of elongation factor 1A by yeast Efm4 or human eEF1A-KMT2 involves a beta-hairpin recognition motif and crosstalks with phosphorylation. Hamey JJ, et al. J Biol Chem, 2024 Feb. PMID 38199565, Free PMC Article
  3. Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Lipson RS, et al. Arch Biochem Biophys, 2010 Aug 15. PMID 20510667, Free PMC Article
  4. Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants. Li Z, et al. Virology, 2014 Jan 5. PMID 24314635
  5. Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases. Couttas TA, et al. Proteomics, 2012 Apr. PMID 22522802

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylation of elongation factor 1A by yeast Efm4 or human eEF1A-KMT2 involves a beta-hairpin recognition motif and crosstalks with phosphorylation.
    Title: Methylation of elongation factor 1A by yeast Efm4 or human eEF1A-KMT2 involves a beta-hairpin recognition motif and crosstalks with phosphorylation.
  2. Methylation of TEF1 by See1 facilitates tombusvirus replication in Saccharomyces cerevisiae.
    Title: Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants.
  3. YHL039W (now designated EFM1 for elongation factor methyltransferase 1) and YIL064W/SEE1 encode distinct eEF1A methyltransferases that respectively monomethylate and dimethylate this protein at lysine residues
    Title: Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae.
  4. These are the first in vivo data reporting a functional role for the protein encoded by ORF YIL064w and identify Yil064p, named here secretion and early endocytosis 1 protein (See1p), as a novel component of intracellular transport.
    Title: Absence of See1p, a widely conserved Saccharomyces cerevisiae protein, confers both deficient heterologous protein production and endocytosis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Efm4p
NP_012200.2
  • Lysine methyltransferase; involved in the dimethylation of eEF1A (Tef1p/Tef2p) at lysine 316; sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    242027..242716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179414.2 → NP_012200.2  TPA: Efm4p

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVM0, P40516, Q6B2R5
    UniProtKB/TrEMBL
    N1P222
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40516.2

Gene LinkOut

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