Format

Send to:

Choose Destination

LBX2 ladybird homeobox 2 [ Homo sapiens (human) ]

Gene ID: 85474, updated on 1-Jun-2020

Summary

Official Symbol
LBX2provided by HGNC
Official Full Name
ladybird homeobox 2provided by HGNC
Primary source
HGNC:HGNC:15525
See related
Ensembl:ENSG00000179528 MIM:607164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LP3727
Expression
Biased expression in liver (RPKM 2.5), small intestine (RPKM 1.7) and 11 other tissues See more
Orthologs

Genomic context

See LBX2 in Genome Data Viewer
Location:
2p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74497517..74503316, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74724644..74730443, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 142 Neighboring gene tetratricopeptide repeat domain 31 Neighboring gene Sharpr-MPRA regulatory region 184 Neighboring gene LBX2 antisense RNA 1 Neighboring gene polycomb group ring finger 1 Neighboring gene T cell leukemia homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor LBX2
Names
ladybird homeobox protein homolog 2
ladybird-like homeobox 2
ladybird-like homeodomain protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009812.2NP_001009812.1  transcription factor LBX2 isoform 2

    See identical proteins and their annotated locations for NP_001009812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' most exon which results in the use of an alternate AUG compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AY305861
    Consensus CDS
    CCDS33228.1
    UniProtKB/Swiss-Prot
    Q6XYB7
    Related
    ENSP00000417116.2, ENST00000460508.3
    Conserved Domains (1) summary
    pfam00046
    Location:84137
    Homeobox; Homeobox domain
  2. NM_001282430.2NP_001269359.1  transcription factor LBX2 isoform 1

    See identical proteins and their annotated locations for NP_001269359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC005041, AY203953, AY305861, BC150517
    Consensus CDS
    CCDS62938.1
    UniProtKB/Swiss-Prot
    Q6XYB7
    Related
    ENSP00000366789.4, ENST00000377566.9
    Conserved Domains (1) summary
    pfam00046
    Location:88141
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74497517..74503316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center