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RPN2 proteasome regulatory particle base subunit RPN2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854735, updated on 8-Sep-2022

Summary

Gene symbol
RPN2
Gene description
proteasome regulatory particle base subunit RPN2
Primary source
SGD:S000001337
Locus tag
YIL075C
See related
AllianceGenome:SGD:S000001337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SEN3
Summary
Enables ubiquitin protein ligase binding activity. Contributes to endopeptidase activity. Involved in proteasome assembly and ubiquitin-dependent protein catabolic process. Located in nucleus and proteasome storage granule. Part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMD1 (proteasome 26S subunit, non-ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See RPN2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (217863..220700, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Rci37p Neighboring gene coatomer subunit epsilon Neighboring gene phosphoglycerate dehydrogenase SER33 Neighboring gene Spo22p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the RPN2 gene: The RPN2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
contributes_to endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasome assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome regulatory particle, base subcomplex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in proteasome storage granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome regulatory particle base subunit RPN2
NP_012190.1
  • Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    217863..220700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179425.1NP_012190.1  TPA: proteasome regulatory particle base subunit RPN2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012190.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVK9, P32565
    UniProtKB/TrEMBL
    A0A0L8VPD3, A0A8H4C1K9, B3LTS6, N1P4H3
    Conserved Domains (2) summary
    COG5116
    Location:1945
    RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    sd00044
    Location:533557
    HEAT; HEAT repeat [structural motif]