U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

THS1 threonine--tRNA ligase THS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854732, updated on 18-Jan-2023

Summary

Gene symbol
THS1
Gene description
threonine--tRNA ligase THS1
Primary source
SGD:S000001340
Locus tag
YIL078W
See related
AllianceGenome:SGD:S000001340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See THS1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (212499..214703)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene TRAMP complex RNA-binding subunit Neighboring gene Rci37p Neighboring gene coatomer subunit epsilon

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the THS1 gene: The THS1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables threonine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables threonine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in threonyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in threonyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
threonine--tRNA ligase THS1
NP_116578.3
  • Threonyl-tRNA synthetase; essential cytoplasmic protein; human homolog TARS can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    212499..214703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179428.3NP_116578.3  TPA: threonine--tRNA ligase THS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116578.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVK6, P04801
    UniProtKB/TrEMBL
    A0A8H4BZ50
    Conserved Domains (1) summary
    PLN02908
    Location:46728
    PLN02908; threonyl-tRNA synthetase