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Polg DNA polymerase gamma, catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 85472, updated on 10-Oct-2019

Summary

Official Symbol
Polgprovided by RGD
Official Full Name
DNA polymerase gamma, catalytic subunitprovided by RGD
Primary source
RGD:620057
See related
Ensembl:ENSRNOG00000032293
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
exhibits DNA polymerase activity; may mediate the final step of mitochondrial DNA repair [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 288.9), Thymus (RPKM 162.7) and 9 other tissues See more
Orthologs

Genomic context

See Polg in Genome Data Viewer
Location:
1q31
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141172117..141188893, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (142133892..142150597, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 2 Neighboring gene retinaldehyde binding protein 1 Neighboring gene FA complementation group I Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene uncharacterized LOC102547943

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
exonuclease activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent DNA replication ISO
Inferred from Sequence Orthology
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
aging ISO
Inferred from Sequence Orthology
more info
PubMed 
base-excision repair, gap-filling IEA
Inferred from Electronic Annotation
more info
 
base-excision repair, gap-filling ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
mitochondrial DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
gamma DNA polymerase complex IDA
Inferred from Direct Assay
more info
PubMed 
gamma DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase subunit gamma-1
Names
DNA-directed DNA polymerase gamma
mitochondrial DNA polymerase catalytic subunit
polG-alpha
polymerase (DNA directed), gamma
polymerase (DNA) gamma, catalytic subunit
NP_445980.1
XP_006229472.1
XP_008757783.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053528.1NP_445980.1  DNA polymerase subunit gamma-1

    See identical proteins and their annotated locations for NP_445980.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ245647
    UniProtKB/Swiss-Prot
    Q9QYV8
    Related
    ENSRNOP00000047900.3, ENSRNOT00000044567.4
    Conserved Domains (2) summary
    cd08641
    Location:7651180
    DNA_pol_gammaA; Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria
    cl02626
    Location:413455
    DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    141172117..141188893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759561.2XP_008757783.1  DNA polymerase subunit gamma-1 isoform X1

    See identical proteins and their annotated locations for XP_008757783.1

    Conserved Domains (3) summary
    cd08641
    Location:7721187
    DNA_pol_gammaA; Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria
    cl02626
    Location:413455
    DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
    cl10012
    Location:248280
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  2. XM_006229410.3XP_006229472.1  DNA polymerase subunit gamma-1 isoform X2

    See identical proteins and their annotated locations for XP_006229472.1

    UniProtKB/Swiss-Prot
    Q9QYV8
    Conserved Domains (3) summary
    cd08641
    Location:7651180
    DNA_pol_gammaA; Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria
    cl02626
    Location:413455
    DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication
    cl10012
    Location:248280
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    125446563..125461666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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