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PRK1 serine/threonine protein kinase PRK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854713, updated on 4-Jan-2025

Summary

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Official Symbol
PRK1
Official Full Name
serine/threonine protein kinase PRK1
Primary source
SGD:S000001357
Locus tag
YIL095W
See related
AllianceGenome:SGD:S000001357; FungiDB:YIL095W; VEuPathDB:YIL095W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PAK1
Summary
Enables protein serine/threonine kinase activity. Involved in actin cortical patch assembly and negative regulation of cellular component organization. Located in actin cortical patch. Orthologous to human AAK1 (AP2 associated kinase 1) and BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PRK1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (183937..186369)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene 25S rRNA (uracil2634-N3)-methyltransferase Neighboring gene tRNA-Ile Neighboring gene homoisocitrate dehydrogenase Neighboring gene mitochondrial 37S ribosomal protein RSM25

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PAK1, a gene that can regulate p53 activity in yeast. Thiagalingam S, et al. Proc Natl Acad Sci U S A, 1995 Jun 20. PMID 7597081, Free PMC Article
  2. Prk1p. Zeng G, et al. Int J Biochem Cell Biol, 2005 Jan. PMID 15381149
  3. Regulation of the yeast formin Bni1p by the actin-regulating kinase Prk1p. Wang J, et al. Traffic, 2009 May. PMID 19220811
  4. Identification of novel recognition motifs and regulatory targets for the yeast actin-regulating kinase Prk1p. Huang B, et al. Mol Biol Cell, 2003 Dec. PMID 13679512, Free PMC Article
  5. Regulation of the actin cytoskeleton organization in yeast by a novel serine/threonine kinase Prk1p. Zeng G, et al. J Cell Biol, 1999 Jan 11. PMID 9885245, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved Ark1-related kinases function in a TORC2 signaling network.
    Title: Conserved Ark1-related kinases function in a TORC2 signaling network.
  2. autophosphorylation of Prk1p may represent a feedback mechanism possibly involved in fine-tuning the pace of progression during actin-coupled endocytosis
    Title: Negative regulation of the actin-regulating kinase Prk1p by patch localization-induced autophosphorylation.
  3. These findings reveal that Arp2p also mediates what appears to be an auto-regulatory mechanism possibly adapted for efficient coordination of actin assembly and disassembly during endocytosis.
    Title: A novel function of Arp2p in mediating Prk1p-specific regulation of actin and endocytosis in yeast.
  4. Overexpressed Prk1 conferred Adriamycin resistance in yeast cells.
    Title: Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells.
  5. Data show that Sjl2p is specifically associated with cortical actin patches which aggregate upon loss of the actin-regulating kinases Ark1p and Prk1p.
    Title: Sjl2p is specifically involved in early steps of endocytosis intimately linked to actin dynamics via the Ark1p/Prk1p kinases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of actin cortical patch assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of clathrin-dependent endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase PRK1
NP_012171.1
  • Ser/Thr protein kinase; regulates the organization and function of the actin cytoskeleton; inhibits clathrin-mediated endocytosis; phosphorylates the Pan1p and Sla1p subunits of the Pan1p-Sla1p-End3p complex, resulting in inhibition of complex formation; inhibits Scd5p through phosphorylation; phosphorylates Pan1p-interacting proteins, Ent1/2 and Yap1801/2; negatively regulated through autophosphorylation; functional overlap with ARK1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    183937..186369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179443.1 → NP_012171.1  TPA: serine/threonine protein kinase PRK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVJ2, P40494, Q02553
    UniProtKB/TrEMBL
    A6ZVI2, B3LTU2, C7GKM2, C8ZAF5, N1P9B6
    Conserved Domains (1) summary
    cd14037
    Location:18 → 300
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40494.1

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