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Gata3 GATA binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85471, updated on 11-Apr-2024

Summary

Official Symbol
Gata3provided by RGD
Official Full Name
GATA binding protein 3provided by RGD
Primary source
RGD:621250
See related
Ensembl:ENSRNOG00000019336 AllianceGenome:RGD:621250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including cochlea development; response to gamma radiation; and type IV hypersensitivity. Located in nucleus. Biomarker of asthma. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 42.6), Kidney (RPKM 29.9) and 4 other tissues See more
Orthologs
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Genomic context

See Gata3 in Genome Data Viewer
Location:
17q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (73544234..73575670)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (68643760..68666000)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (72419752..72452043)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102546431 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene uncharacterized LOC120097843 Neighboring gene uncharacterized LOC134482600 Neighboring gene uncharacterized LOC102546657 Neighboring gene uncharacterized LOC120097778

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables HMG box domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-2 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac right ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell fate determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within developmental growth ISO
Inferred from Sequence Orthology
more info
 
involved_in ear development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within humoral immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in immune system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mast cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchymal to epithelial transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesonephros development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA demethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation involved in mesonephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in nephric duct formation ISO
Inferred from Sequence Orthology
more info
 
involved_in nephric duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within otic vesicle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within parathyroid gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within parathyroid hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pro-T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T-helper cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to X-ray ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nephron tubule epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sympathetic nervous system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymic T cell selection ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in type IV hypersensitivity IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within ureter maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ureter morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
involved_in uterus development ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular septum development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
trans-acting T-cell-specific transcription factor GATA-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133293.3NP_579827.1  trans-acting T-cell-specific transcription factor GATA-3

    See identical proteins and their annotated locations for NP_579827.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5
    Related
    ENSRNOP00000026187.3, ENSRNOT00000026187.6
    Conserved Domains (1) summary
    cd00202
    Location:317367
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    73544234..73575670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276782.1XP_063132852.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X1

    UniProtKB/TrEMBL
    A6JLV3, F7FAR3, Q99NH5
  2. XM_063276783.1XP_063132853.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X2

  3. XM_017600667.3XP_017456156.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6L1
    Conserved Domains (1) summary
    cd00202
    Location:316366
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  4. XM_063276784.1XP_063132854.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X3

  5. XM_063276785.1XP_063132855.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X4

  6. XM_008771893.3XP_008770115.1  trans-acting T-cell-specific transcription factor GATA-3 isoform X1

    See identical proteins and their annotated locations for XP_008770115.1

    UniProtKB/TrEMBL
    A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5
    Conserved Domains (1) summary
    cd00202
    Location:317367
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C