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SEC24 COPII subunit SEC24 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854697, updated on 18-Jan-2023

Summary

Gene symbol
SEC24
Gene description
COPII subunit SEC24
Primary source
SGD:S000001371
Locus tag
YIL109C
See related
AllianceGenome:SGD:S000001371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ANU1
Summary
Enables signal sequence binding activity. Involved in COPII-coated vesicle cargo loading and macroautophagy. Located in fungal-type vacuole membrane. Part of COPII vesicle coat. Orthologous to human SEC24A (SEC24 homolog A, COPII coat complex component) and SEC24B (SEC24 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SEC24 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (157385..160165, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit Vb Neighboring gene protein-histidine N-methyltransferase Neighboring gene putative metalloendopeptidase Neighboring gene 6-phosphofructo-2-kinase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SEC24 gene: The SEC24 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables signal sequence binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in COPII-coated vesicle cargo loading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
 
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COPII subunit SEC24
NP_012157.3
  • Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    157385..160165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179457.3NP_012157.3  TPA: COPII subunit SEC24 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012157.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVH8, P40482
    UniProtKB/TrEMBL
    A0A0L8VNI0, A0A7I9BTX5, A6ZVG8, C7GKN5
    Conserved Domains (1) summary
    COG5028
    Location:1926
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]