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NUP159 FG-nucleoporin NUP159 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854691, updated on 17-May-2024

Summary

Gene symbol
NUP159
Gene description
FG-nucleoporin NUP159
Primary source
FungiDB:YIL115C
Locus tag
YIL115C
See related
SGD:S000001377; AllianceGenome:SGD:S000001377; VEuPathDB:YIL115C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NUP158; RAT7
Summary
Enables adenyl-nucleotide exchange factor activity. A structural constituent of nuclear pore. Involved in nuclear pore localization; nucleocytoplasmic transport; and selective autophagy. Part of nuclear pore central transport channel and nuclear pore cytoplasmic filaments. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See NUP159 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (144327..148709, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene pheromone-regulated protein PRM5 Neighboring gene histidinol-phosphate transaminase Neighboring gene putative porin POR2 Neighboring gene mitogen-activated protein kinase tyrosine protein phosphatase SDP1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural constituent of nuclear pore IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore central transport channel IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore cytoplasmic filaments IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
FG-nucleoporin NUP159
NP_012151.1
  • FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    144327..148709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179463.1NP_012151.1  TPA: FG-nucleoporin NUP159 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVH2, P40477
    UniProtKB/TrEMBL
    A0A8H4C1L0, B3LTW2
    Conserved Domains (5) summary
    PTZ00395
    Location:558874
    PTZ00395; Sec24-related protein; Provisional
    COG5271
    Location:8921163
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    COG5651
    Location:142673
    COG5651; PPE-repeat protein [Function unknown]
    PRK08581
    Location:7511006
    PRK08581; amidase domain-containing protein
    pfam16755
    Location:24380
    NUP214; Nucleoporin or Nuclear pore complex subunit NUP214=Nup159