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RHO3 Rho family GTPase RHO3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854688, updated on 2-Nov-2024

Summary

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Official Symbol
RHO3
Official Full Name
Rho family GTPase RHO3
Primary source
SGD:S000001380
Locus tag
YIL118W
See related
AllianceGenome:SGD:S000001380; FungiDB:YIL118W; VEuPathDB:YIL118W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTP binding activity and GTPase activity. Involved in establishment or maintenance of actin cytoskeleton polarity; positive regulation of exocytosis; and positive regulation of formin-nucleated actin cable assembly. Located in cellular bud and cytosol. Orthologous to several human genes including RND1 (Rho family GTPase 1); RND2 (Rho family GTPase 2); and RND3 (Rho family GTPase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RHO3 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (139752..140447)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene multidrug transporter Neighboring gene Rpi1p Neighboring gene pheromone-regulated protein PRM5 Neighboring gene histidinol-phosphate transaminase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactions of the Trichoderma reesei rho3 with the secretory pathway in yeast and T. reesei. Vasara T, et al. Mol Microbiol, 2001 Dec. PMID 11886564
  2. Trichoderma reesei rho3 a homologue of yeast RH03 suppresses the growth defect of yeast sec15-1 mutation. Vasara T, et al. Curr Genet, 2001 Sep. PMID 11680821
  3. Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae. Matsui Y, et al. Gene, 1992 May 1. PMID 1587484
  4. Evidence for specific interaction between the RhoGAP domain from the yeast Rgd1 protein and phosphoinositides. Odaert B, et al. Biochem Biophys Res Commun, 2011 Feb 4. PMID 21215255
  5. Crystal structure of the S.cerevisiae exocyst component Exo70p. Hamburger ZA, et al. J Mol Biol, 2006 Feb 10. PMID 16359701

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
    Title: The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
  2. Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
    Title: Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
  3. The authors propose that Tos2p, a protein involved in polarized growth and most probably associated with the plasma membrane, modulates the action of Rgd1p and Rho3p in Saccharomyces cerevisiae.
    Title: Evidence for functional links between the Rgd1-Rho3 RhoGAP-GTPase module and Tos2, a protein involved in polarized growth in Saccharomyces cerevisiae.
  4. a small region at the N terminus is necessary and sufficient to confer Rho3 localization and function onto Cdc42
    Title: The function of two Rho family GTPases is determined by distinct patterns of cell surface localization.
  5. Data show that Exo70 has the biochemical properties expected of a direct effector for both Rho3 and Cdc42, and suggest that interaction with the Exo70 component of the exocyst is a key event in spatial regulation of exocytosis by Rho GTPases.
    Title: The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis.
  6. The ability of Rho3 and Cdc42 to hydrolyze GTP is not required for their role in secretion.
    Title: Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.
  7. Wsc1p participates in the regulation of a Rho3/4-dependent cellular mechanism.
    Title: The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of formin-nucleated actin cable assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho family GTPase RHO3
NP_012148.1
  • Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    139752..140447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179466.1 → NP_012148.1  TPA: Rho family GTPase RHO3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012148.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVG9, Q00245
    UniProtKB/TrEMBL
    A6ZVF9, B3LTW5, B5VKJ1, C8ZAC6, G2WG33, N1P9A6
    Conserved Domains (1) summary
    cd04134
    Location:17 → 231
    Rho3; Ras homology family 3 (Rho3) of small guanosine triphosphatases (GTPases)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00245.2

Gene LinkOut

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