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SSL2 TFIIH/NER complex ATPase/helicase subunit SSL2 [ Saccharomyces cerevisiae S288c ]

Gene ID: 854663, updated on 5-Mar-2017
Gene symbol
SSL2
Gene description
TFIIH/NER complex ATPase/helicase subunit SSL2
Primary source
SGD:S000001405
Locus tag
YIL143C
Gene type
protein coding
RNA name
TFIIH/NER complex ATPase/helicase subunit SSL2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LOM3; RAD25
See SSL2 in Map Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (80510..83041, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene pantoate--beta-alanine ligase PAN6 Neighboring gene kinetochore-associated Ndc80 complex subunit NDC80 Neighboring gene chaperonin-containing T-complex subunit CCT2 Neighboring gene Axl2p

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP-dependent DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA translocase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to transcription factor activity, core RNA polymerase binding IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair, DNA incision IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation of RNA polymerase II C-terminal domain IDA
Inferred from Direct Assay
more info
PubMed 
poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
promoter clearance from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transposition, RNA-mediated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcriptional open complex formation at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with core TFIIH complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
holo TFIIH complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-excision repair factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transcriptional preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
Names
TFIIH/NER complex ATPase/helicase subunit SSL2
NP_012123.1
  • Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    80510..83041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179491.1NP_012123.1  TPA: TFIIH/NER complex ATPase/helicase subunit SSL2 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_012123.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00578
    Conserved Domains (4) summary
    TIGR00603
    Location:117835
    rad25; DNA repair helicase rad25
    pfam04851
    Location:361519
    ResIII; Type III restriction enzyme, res subunit
    pfam13625
    Location:132255
    Helicase_C_3; Helicase conserved C-terminal domain
    pfam16203
    Location:543784
    ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase
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