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MCM10 Mcm10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854656, updated on 3-Nov-2024

Summary

Official Symbol
MCM10
Official Full Name
Mcm10p
Primary source
SGD:S000001412
Locus tag
YIL150C
See related
AllianceGenome:SGD:S000001412; FungiDB:YIL150C; VEuPathDB:YIL150C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DNA43
Summary
Enables DNA replication origin binding activity and single-stranded DNA binding activity. Involved in DNA metabolic process and constitutive heterochromatin formation. Acts upstream of or within mitotic DNA replication DNA duplex unwinding. Located in nucleus and replication fork. Part of replication fork protection complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See MCM10 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (61013..62728, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Vpr1p Neighboring gene Esl1p Neighboring gene Mlp2p Neighboring gene ubiquitin-ribosomal 60S subunit protein L40A fusion protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in replication fork IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of replication fork protection complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Mcm10p
NP_012116.1
  • Essential chromatin-associated protein; involved in initiation of DNA replication; promotes origin duplex unwinding by head-to-head CMG helicase complexes; required for association of MCM2-7 complex with replication origins; required to stabilize the catalytic subunit of DNA polymerase-alpha; coordinates function of the replication fork helicase; self-associates through its N-terminal domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    61013..62728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179498.1NP_012116.1  TPA: Mcm10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012116.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVD7, P32354
    UniProtKB/TrEMBL
    A6ZVC6, N1P1T0
    Conserved Domains (1) summary
    pfam09329
    Location:301347
    zf-primase; Primase zinc finger