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ZC3H12C zinc finger CCCH-type containing 12C [ Homo sapiens (human) ]

Gene ID: 85463, updated on 13-Mar-2020

Summary

Official Symbol
ZC3H12Cprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 12Cprovided by HGNC
Primary source
HGNC:HGNC:29362
See related
Ensembl:ENSG00000149289 MIM:615001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCPIP3
Expression
Ubiquitous expression in thyroid (RPKM 3.1), colon (RPKM 2.2) and 25 other tissues See more
Orthologs

Genomic context

See ZC3H12C in Genome Data Viewer
Location:
11q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (110092425..110171841)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (109963673..110042566)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984384 Neighboring gene ribosomal protein SA pseudogene 50 Neighboring gene RNA polymerase II subunit E pseudogene Neighboring gene VISTA enhancer hs1311 Neighboring gene radixin Neighboring gene uncharacterized LOC107984385 Neighboring gene long intergenic non-protein coding RNA 2732

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1726

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
probable ribonuclease ZC3H12C
Names
MCP-induced protein 3
zinc finger CCCH domain-containing protein 12C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033390.2NP_203748.1  probable ribonuclease ZC3H12C

    See identical proteins and their annotated locations for NP_203748.1

    Status: VALIDATED

    Source sequence(s)
    AB096241, AL832893, AP000901, AP001889
    Consensus CDS
    CCDS44727.1
    UniProtKB/Swiss-Prot
    Q9C0D7
    Related
    ENSP00000278590.3, ENST00000278590.8
    Conserved Domains (1) summary
    pfam11977
    Location:244400
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    110092425..110171841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543055.2XP_011541357.1  probable ribonuclease ZC3H12C isoform X3

    See identical proteins and their annotated locations for XP_011541357.1

    UniProtKB/TrEMBL
    E9PP00
    Related
    ENSP00000413094.2, ENST00000453089.2
    Conserved Domains (1) summary
    pfam11977
    Location:213369
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  2. XM_005271715.4XP_005271772.1  probable ribonuclease ZC3H12C isoform X1

    See identical proteins and their annotated locations for XP_005271772.1

    Conserved Domains (1) summary
    pfam11977
    Location:245401
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
  3. XM_017018477.2XP_016873966.1  probable ribonuclease ZC3H12C isoform X2

    UniProtKB/Swiss-Prot
    Q9C0D7
    Related
    ENSP00000431821.1, ENST00000528673.5
    Conserved Domains (1) summary
    pfam11977
    Location:245401
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
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