HSP33 glutathione-independent methylglyoxalase family protein [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: HSP33
Official Full Name: glutathione-independent methylglyoxalase family protein
Primary source: SGD:S000005918
Locus tag: YOR391C
See related: AllianceGenome:SGD:S000005918; FungiDB:YOR391C; VEuPathDB:YOR391C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable glyoxalase III activity and protein folding chaperone. Involved in cellular response to nutrient levels. Predicted to be located in P-body. Predicted to be active in cytoplasm. Used to study Parkinson's disease and cancer. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glyoxalase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyoxalase III activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

NP_015036.3

Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer

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