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TNKS1BP1 tankyrase 1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 85456, updated on 7-Sep-2023

Summary

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Official Symbol
TNKS1BP1provided by HGNC
Official Full Name
tankyrase 1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:19081
See related
Ensembl:ENSG00000149115 MIM:607104; AllianceGenome:HGNC:19081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNOT12; TAB182
Summary
Enables ankyrin repeat binding activity and enzyme binding activity. Involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Located in several cellular components, including actin cytoskeleton; adherens junction; and heterochromatin. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 32.4), fat (RPKM 31.8) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See TNKS1BP1 in Genome Data Viewer
Location:
11q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57299642..57324952, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57249129..57274443, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57067116..57092426, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57004366-57004998 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:57008040-57008806 Neighboring gene Sharpr-MPRA regulatory region 4343 Neighboring gene apelin receptor Neighboring gene uncharacterized LOC107984364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57051243-57052127 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57067393-57068592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57070511-57071048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071049-57071584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071585-57072121 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57092719-57093592 Neighboring gene small nucleolar RNA U13 Neighboring gene structure specific recognition protein 1 Neighboring gene purinergic receptor P2X 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57117303-57117802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57132373-57132874 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57136946-57138145

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing TAB182 inhibits cell EMT, migration and invasion by downregulating EGFR in A549 NSCLC cells. Wang S, et al. Mol Biol Rep, 2023 Apr. PMID 36689051
  2. TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner. Gao A, et al. Cell Death Dis, 2022 Oct 26. PMID 36289198, Free PMC Article
  3. Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion. Ohishi T, et al. Cancer Res, 2017 May 1. PMID 28202517
  4. Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks. Tan W, et al. Cancer Med, 2017 Feb. PMID 28058814, Free PMC Article
  5. Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience. Gelmini S, et al. Clin Chem Lab Med, 2007. PMID 17617028

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing TAB182 inhibits cell EMT, migration and invasion by downregulating EGFR in A549 NSCLC cells.
    Title: Silencing TAB182 inhibits cell EMT, migration and invasion by downregulating EGFR in A549 NSCLC cells.
  2. TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing beta-catenin nuclear translocation through FHL2 dependent manner.
    Title: TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner.
  3. Tissue-Specific Regulation of the Wnt/beta-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
    Title: Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
  4. TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer.
    Title: TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer.
  5. Results found that TNKS1BP1 was upregulated in human lung adenocarcinoma tissues, and regulates genome stability, mainly through affecting the homologous recombination pathway of DNA double-strand breaks. These results indicate that overexpression of TNKS1BP1 might affect the outcomes of lung cancer patients to chemotherapy and radiotherapy.
    Title: Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks.
  6. In clinical samples of pancreatic cancer, TNKS1BP1 expression was reduced in invasive regions. We propose that the tankyrase-TNKS1BP1 axis constitutes a posttranslational modulator of cell invasion whose aberration promotes cancer malignancy
    Title: Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion.
  7. TNKS1BP1 has a role in DNA double-strand break repair though DNA-PKcs autophosphorylation which is dependent on PARP-1
    Title: TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.
  8. TNKS-1 mRNA in urine sediment from patients with bladder TCC correlated with tumor stage, and higher preoperative levels were associated with increased risk of early recurrence.
    Title: Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.
  9. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).
    Title: The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).
  10. Identification of a tankyrase-binding motif in this protein.
    Title: Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45975, KIAA1741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ankyrin repeat binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ankyrin repeat binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via telomerase NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CCR4-NOT complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
182 kDa tankyrase-1-binding protein
Names
tankyrase 1 binding protein 1, 182kDa
tankyrase 1-binding protein of 182 kDa
testis secretory sperm-binding protein Li 206a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033396.3 → NP_203754.2  182 kDa tankyrase-1-binding protein

    See identical proteins and their annotated locations for NP_203754.2

    Status: VALIDATED

    Source sequence(s)
    AA614752, AB051528, AF441771, AP000781, CT003184
    Consensus CDS
    CCDS7951.1
    UniProtKB/Swiss-Prot
    A7E2F8, Q6PJ35, Q6ZV74, Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Related
    ENSP00000350990.3, ENST00000358252.8
    Conserved Domains (1) summary
    pfam15327
    Location:1557 → 1721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57299642..57324952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718725.4 → XP_006718788.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006718788.1

    UniProtKB/Swiss-Prot
    A7E2F8, Q6PJ35, Q6ZV74, Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Related
    ENSP00000437271.1, ENST00000532437.1
    Conserved Domains (1) summary
    pfam15327
    Location:1557 → 1721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

  2. XM_047427785.1 → XP_047283741.1  182 kDa tankyrase-1-binding protein isoform X3

  3. XM_011545325.4 → XP_011543627.1  182 kDa tankyrase-1-binding protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:95 → 463
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:273 → 691
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57249129..57274443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370325.1 → XP_054226300.1  182 kDa tankyrase-1-binding protein isoform X1

  2. XM_054370327.1 → XP_054226302.1  182 kDa tankyrase-1-binding protein isoform X3

  3. XM_054370326.1 → XP_054226301.1  182 kDa tankyrase-1-binding protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0C2.4 GenPept UniProtKB/Swiss-Prot:Q9C0C2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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