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TNKS1BP1 tankyrase 1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 85456, updated on 9-Jun-2025
Official Symbol
TNKS1BP1provided by HGNC
Official Full Name
tankyrase 1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:19081
See related
Ensembl:ENSG00000149115 MIM:607104; AllianceGenome:HGNC:19081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNOT12; TAB182
Summary
Enables ankyrin repeat binding activity; enzyme binding activity; and protein serine/threonine kinase activator activity. Involved in cellular response to ionizing radiation and double-strand break repair. Located in several cellular components, including adherens junction; heterochromatin; and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in skin (RPKM 32.4), fat (RPKM 31.8) and 24 other tissues See more
Orthologs
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See TNKS1BP1 in Genome Data Viewer
Location:
11q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57299642..57324952, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57249129..57274443, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57067116..57092426, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57004366-57004998 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:57008040-57008806 Neighboring gene Sharpr-MPRA regulatory region 4343 Neighboring gene apelin receptor Neighboring gene uncharacterized LOC107984364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57051243-57052127 Neighboring gene MPRA-validated peak1278 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57067393-57068592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57070511-57071048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071049-57071584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071585-57072121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3343 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57092719-57093592 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4716 Neighboring gene structure specific recognition protein 1 Neighboring gene purinergic receptor P2X 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57117303-57117802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57132373-57132874 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57136946-57138145

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ45975, KIAA1741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ankyrin repeat binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ankyrin repeat binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding HDA PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
Non-traceable Author Statement
more info
PubMed 
involved_in telomere maintenance via telomerase NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CCR4-NOT complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
182 kDa tankyrase-1-binding protein
Names
tankyrase 1 binding protein 1, 182kDa
tankyrase 1-binding protein of 182 kDa
testis secretory sperm-binding protein Li 206a

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033396.3NP_203754.2  182 kDa tankyrase-1-binding protein

    See identical proteins and their annotated locations for NP_203754.2

    Status: VALIDATED

    Source sequence(s)
    AA614752, AB051528, AF441771, AP000781, CT003184
    Consensus CDS
    CCDS7951.1
    UniProtKB/Swiss-Prot
    A7E2F8, Q6PJ35, Q6ZV74, Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Related
    ENSP00000350990.3, ENST00000358252.8
    Conserved Domains (1) summary
    pfam15327
    Location:15571721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57299642..57324952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718725.4XP_006718788.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006718788.1

    UniProtKB/Swiss-Prot
    A7E2F8, Q6PJ35, Q6ZV74, Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Related
    ENSP00000437271.1, ENST00000532437.1
    Conserved Domains (1) summary
    pfam15327
    Location:15571721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain
  2. XM_047427785.1XP_047283741.1  182 kDa tankyrase-1-binding protein isoform X3

  3. XM_011545325.4XP_011543627.1  182 kDa tankyrase-1-binding protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:95463
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:273691
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57249129..57274443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370325.1XP_054226300.1  182 kDa tankyrase-1-binding protein isoform X1

  2. XM_054370327.1XP_054226302.1  182 kDa tankyrase-1-binding protein isoform X3

  3. XM_054370326.1XP_054226301.1  182 kDa tankyrase-1-binding protein isoform X2