Format

Send to:

Choose Destination

TNKS1BP1 tankyrase 1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 85456, updated on 17-Jun-2019

Summary

Official Symbol
TNKS1BP1provided by HGNC
Official Full Name
tankyrase 1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:19081
See related
Ensembl:ENSG00000149115 MIM:607104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAB182
Expression
Ubiquitous expression in skin (RPKM 32.4), fat (RPKM 31.8) and 24 other tissues See more
Orthologs

Genomic context

See TNKS1BP1 in Genome Data Viewer
Location:
11q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57299631..57324952, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57067103..57092485, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene apelin receptor Neighboring gene uncharacterized LOC107984364 Neighboring gene structure specific recognition protein 1 Neighboring gene purinergic receptor P2X 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
    Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
  • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
    Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemUnder a variety of stress conditions, TP53 (p53), stabilized by stress-induced phosphorylation at least on S15 and S20 serine residues, can induce the transcription of genes involved in cell cycle ar...
  • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystem (from REACTOME)
    TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystemBTG2 is induced by TP53, leading to cessation of cellular proliferation (Rouault et al. 1996, Duriez et al. 2002). BTG2 binds to the CCR4-NOT complex and promotes mRNA deadenylation activity of this ...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45975, KIAA1741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ankyrin repeat binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ankyrin repeat binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
182 kDa tankyrase-1-binding protein
Names
tankyrase 1 binding protein 1, 182kDa
tankyrase 1-binding protein of 182 kDa
testis secretory sperm-binding protein Li 206a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033396.3NP_203754.2  182 kDa tankyrase-1-binding protein

    See identical proteins and their annotated locations for NP_203754.2

    Status: VALIDATED

    Source sequence(s)
    AA614752, AB051528, AF441771, AP000781, CT003184
    Consensus CDS
    CCDS7951.1
    UniProtKB/Swiss-Prot
    Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Related
    ENSP00000350990.3, ENST00000358252.8
    Conserved Domains (1) summary
    pfam15327
    Location:15571721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57299631..57324952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718725.3XP_006718788.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006718788.1

    UniProtKB/Swiss-Prot
    Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Conserved Domains (1) summary
    pfam15327
    Location:15571721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain
  2. XM_011545325.3XP_011543627.1  182 kDa tankyrase-1-binding protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:95463
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:273691
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
Support Center