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TNKS1BP1 tankyrase 1 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 85456, updated on 6-Sep-2022

Summary

Official Symbol
TNKS1BP1provided by HGNC
Official Full Name
tankyrase 1 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:19081
See related
Ensembl:ENSG00000149115 MIM:607104; AllianceGenome:HGNC:19081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAB182
Summary
Enables ankyrin repeat binding activity and enzyme binding activity. Involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Located in several cellular components, including actin cytoskeleton; adherens junction; and heterochromatin. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 32.4), fat (RPKM 31.8) and 24 other tissues See more
Orthologs
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Genomic context

See TNKS1BP1 in Genome Data Viewer
Location:
11q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57299642..57324952, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57249129..57274443, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57067116..57092426, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4343 Neighboring gene uncharacterized LOC107984364 Neighboring gene small nucleolar RNA U13 Neighboring gene structure specific recognition protein 1 Neighboring gene purinergic receptor P2X 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45975, KIAA1741

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ankyrin repeat binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ankyrin repeat binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding HDA PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IC
Inferred by Curator
more info
PubMed 
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
182 kDa tankyrase-1-binding protein
Names
tankyrase 1 binding protein 1, 182kDa
tankyrase 1-binding protein of 182 kDa
testis secretory sperm-binding protein Li 206a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033396.3NP_203754.2  182 kDa tankyrase-1-binding protein

    See identical proteins and their annotated locations for NP_203754.2

    Status: VALIDATED

    Source sequence(s)
    AA614752, AB051528, AF441771, AP000781, CT003184
    Consensus CDS
    CCDS7951.1
    UniProtKB/Swiss-Prot
    Q6ZV74, Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Related
    ENSP00000350990.3, ENST00000358252.8
    Conserved Domains (1) summary
    pfam15327
    Location:15571721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57299642..57324952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718725.4XP_006718788.1  182 kDa tankyrase-1-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006718788.1

    UniProtKB/Swiss-Prot
    Q6ZV74, Q9C0C2
    UniProtKB/TrEMBL
    A0A024R542
    Related
    ENSP00000437271.1, ENST00000532437.1
    Conserved Domains (1) summary
    pfam15327
    Location:15571721
    Tankyrase_bdg_C; Tankyrase binding protein C terminal domain
  2. XM_047427785.1XP_047283741.1  182 kDa tankyrase-1-binding protein isoform X3

  3. XM_011545325.4XP_011543627.1  182 kDa tankyrase-1-binding protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:95463
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:273691
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57249129..57274443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)