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ALD4 aldehyde dehydrogenase (NADP(+)) ALD4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854556, updated on 1-Jul-2024

Summary

Gene symbol
ALD4
Gene description
aldehyde dehydrogenase (NADP(+)) ALD4
Primary source
FungiDB:YOR374W
Locus tag
YOR374W
See related
SGD:S000005901; AllianceGenome:SGD:S000005901; VEuPathDB:YOR374W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ALD7
Summary
Enables aldehyde dehydrogenase (NAD+) activity. Involved in NADPH regeneration; ethanol metabolic process; and monocarboxylic acid metabolic process. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); isolated microphthalmia 8; and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ALD4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1039840..1041399)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ndd1p Neighboring gene Nud1p Neighboring gene glutamate dehydrogenase (NADP(+)) GDH1 Neighboring gene uncharacterized protein

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in NADPH regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in acetate biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ethanol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyruvate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aldehyde dehydrogenase (NADP(+)) ALD4
NP_015019.1
  • Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1039840..1041399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183794.1NP_015019.1  TPA: aldehyde dehydrogenase (NADP(+)) ALD4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015019.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W367, P46367, Q08898
    UniProtKB/TrEMBL
    A0A6A5Q4N4, A6ZPK2, B5VSP8, C8ZHC2, G2WNN4, N1NZ13
    Conserved Domains (1) summary
    cd07091
    Location:42514
    ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins