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DISP2 dispatched RND transporter family member 2 [ Homo sapiens (human) ]

Gene ID: 85455, updated on 23-Nov-2021

Summary

Official Symbol
DISP2provided by HGNC
Official Full Name
dispatched RND transporter family member 2provided by HGNC
Primary source
HGNC:HGNC:19712
See related
Ensembl:ENSG00000140323 MIM:607503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DISPB; C15orf36; HsT16908; LINC00594
Summary
This gene is one of two human homologs of a segment-polarity gene known as dispatched identified in Drosophila. The product of this gene may be required for normal Hedgehog (Hh) signaling during embryonic pattern formation. [provided by RefSeq, Jan 2017]
Expression
Biased expression in brain (RPKM 3.0), small intestine (RPKM 2.9) and 9 other tissues See more
Orthologs
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Genomic context

See DISP2 in Genome Data Viewer
Location:
15q15.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40354359..40378621)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40650420..40670822)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6286 Neighboring gene RNA, 5S ribosomal pseudogene 392 Neighboring gene coiled-coil domain containing 9B Neighboring gene proline, histidine and glycine rich 1 Neighboring gene kinetochore localized astrin (SPAG5) binding protein Neighboring gene isovaleryl-CoA dehydrogenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1742, DKFZp547N223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in smoothened signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein dispatched homolog 2
Names
dispatched B
long intergenic non-protein coding RNA 594

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033510.3NP_277045.1  protein dispatched homolog 2

    See identical proteins and their annotated locations for NP_277045.1

    Status: REVIEWED

    Source sequence(s)
    AB051529, AC013356, CB305650, HY171765
    Consensus CDS
    CCDS10056.1
    UniProtKB/Swiss-Prot
    A7MBM2
    Related
    ENSP00000267889.3, ENST00000267889.5
    Conserved Domains (1) summary
    cl21543
    Location:580646
    MMPL; MMPL family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    40354359..40378621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522125.3XP_011520427.1  protein dispatched homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011520427.1

    UniProtKB/Swiss-Prot
    A7MBM2
    Conserved Domains (1) summary
    cl21543
    Location:580646
    MMPL; MMPL family
  2. XM_017022687.2XP_016878176.1  protein dispatched homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    A7MBM2
    Conserved Domains (1) summary
    cl21543
    Location:580646
    MMPL; MMPL family
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