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PDE2 3',5'-cyclic-nucleotide phosphodiesterase PDE2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854542, updated on 30-Jun-2022

Summary

Gene symbol
PDE2
Gene description
3',5'-cyclic-nucleotide phosphodiesterase PDE2
Primary source
SGD:S000005887
Locus tag
YOR360C
See related
AllianceGenome:SGD:S000005887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SRA5
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74 and primary pigmented nodular adrenocortical disease. Orthologous to several human genes including PDE8A (phosphodiesterase 8A); PDE8B (phosphodiesterase 8B); and PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PDE2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1013241..1014821, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Hap5p Neighboring gene Vts1p Neighboring gene translation initiation factor eIF3 core subunit b Neighboring gene proteasome core particle subunit alpha 7

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3',5'-cyclic-nucleotide phosphodiesterase PDE2
NP_015005.1
  • High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1013241..1014821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183780.1NP_015005.1  TPA: 3',5'-cyclic-nucleotide phosphodiesterase PDE2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015005.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06776
    Conserved Domains (1) summary
    pfam00233
    Location:264513
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase