PDE2 3',5'-cyclic-nucleotide phosphodiesterase PDE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PDE2
Official Full Name: 3',5'-cyclic-nucleotide phosphodiesterase PDE2
Primary source: SGD:S000005887
Locus tag: YOR360C
See related: AllianceGenome:SGD:S000005887; FungiDB:YOR360C; VEuPathDB:YOR360C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SRA5
Summary: Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in acrodysostosis; alcohol dependence; autosomal dominant nonsyndromic deafness 74; congestive heart failure; and primary pigmented nodular adrenocortical disease 3. Orthologous to several human genes including PDE4A (phosphodiesterase 4A); PDE4B (phosphodiesterase 4B); and PDE4C (phosphodiesterase 4C). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
Title: Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
The overexpressed genes, YAP1, PDE2, and STB3, can enhance the tolerance of yeast cells to 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine.
Title: Overexpression of the YAP1, PDE2, and STB3 genes enhances the tolerance of yeast to oxidative stress induced by 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine.
Both SSD1 and PDE2 seemed to improve ethanol tolerance by maintaining robustness of the yeast cell wall.
Title: Overexpression of PDE2 or SSD1-V in Saccharomyces cerevisiae W303-1A strain renders it ethanol-tolerant.
These results suggest that, like its low-affinity counterpart, the high-affinity phosphodiesterase may also play an important role in the PKA-controlled feedback inhibition of intracellular cAMP.
Title: The localization and concentration of the PDE2-encoded high-affinity cAMP phosphodiesterase is regulated by cAMP-dependent protein kinase A in the yeast Saccharomyces cerevisiae.
VEGF increased cAMP-hydrolytic activity by up-regulating the expression of PDE2 and PDE4 isozymes
Title: Modulation of VEGF-induced endothelial cell cycle protein expression through cyclic AMP hydrolysis by PDE2 and PDE4.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP/PKA signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_015005.1

High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon