U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRO2 glutamate-5-semialdehyde dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854501, updated on 23-Apr-2026
Official Symbol
PRO2
Official Full Name
glutamate-5-semialdehyde dehydrogenase
Primary source
SGD:S000005850
Locus tag
YOR323C
See related
AllianceGenome:SGD:S000005850; FungiDB:YOR323C; VEuPathDB:YOR323C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutamate-5-semialdehyde dehydrogenase activity. Involved in proline biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PRO2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (921535..922905, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 Neighboring gene Ldb19p Neighboring gene Frt1p Neighboring gene myosin 2

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. L-proline accumulation and freeze tolerance of Saccharomyces cerevisiae are caused by a mutation in the PRO1 gene encoding gamma-glutamyl kinase. Morita Y, et al. Appl Environ Microbiol, 2003 Jan. PMID 12513997, Free PMC Article
  2. Pro-oxidant action of diphenyl diselenide in the yeast Saccharomyces cerevisiae exposed to ROS-generating conditions. Moreira Rosa R, et al. Life Sci, 2005 Sep 23. PMID 15932762
  3. Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. Tomenchok DM, et al. J Bacteriol, 1987 Dec. PMID 2824433, Free PMC Article
  4. A genetic investigation of the essential role of glutathione: mutations in the proline biosynthesis pathway are the only suppressors of glutathione auxotrophy in yeast. Spector D, et al. J Biol Chem, 2001 Mar 9. PMID 11084050
  5. Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae. Mukai Y, et al. Microb Cell, 2019 Sep 24. PMID 31646149, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate-5-semialdehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
Preferred Names
glutamate-5-semialdehyde dehydrogenase
NP_014968.1
  • Cytosolic gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    921535..922905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183743.1 → NP_014968.1  glutamate-5-semialdehyde dehydrogenase

    See identical proteins and their annotated locations for NP_014968.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W321, P54885
    UniProtKB/TrEMBL
    A6ZPF6, B3LJY5, C7GNU0, C8ZH74, G2WNI8, N1NW80
    Conserved Domains (1) summary
    TIGR00407
    Location:11 → 422
    proA; gamma-glutamyl phosphate reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54885.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous