Format

Send to:

Choose Destination

ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein [ Homo sapiens (human) ]

Gene ID: 85450, updated on 21-Dec-2019

Summary

Official Symbol
ITPRIPprovided by HGNC
Official Full Name
inositol 1,4,5-trisphosphate receptor interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:29370
See related
Ensembl:ENSG00000148841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DANGER; KIAA1754; bA127L20; bA127L20.2
Summary
This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Broad expression in bone marrow (RPKM 60.0), esophagus (RPKM 14.1) and 17 other tissues See more
Orthologs

Genomic context

See ITPRIP in Genome Data Viewer
Location:
10q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (104309696..104338465, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106069454..106098251, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase omega 1 Neighboring gene microRNA 4482 Neighboring gene glutathione S-transferase omega 2 Neighboring gene ITPRIP antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 11867 Neighboring gene CFAP58 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ITPRIP; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1754

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inositol 1,4,5-trisphosphate receptor-interacting protein
Names
inositol 1,4,5-triphosphate receptor-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272012.1NP_001258941.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

    See identical proteins and their annotated locations for NP_001258941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA085530, AK056526, AK094802, BC040536, BG007055, BQ014093, BX436559, CA446720, DA416329, DA832442, DB014126, DR763519
    Consensus CDS
    CCDS7557.1
    UniProtKB/Swiss-Prot
    Q8IWB1
    Related
    ENSP00000350915.2, ENST00000358187.2
    Conserved Domains (3) summary
    pfam03281
    Location:351479
    Mab-21; Mab-21 protein
    pfam06936
    Location:43112
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:1273
    DivIC; Septum formation initiator
  2. NM_001272013.2NP_001258942.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

    See identical proteins and their annotated locations for NP_001258942.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL162742
    Consensus CDS
    CCDS7557.1
    UniProtKB/Swiss-Prot
    Q8IWB1
    Related
    ENSP00000337178.1, ENST00000337478.3
    Conserved Domains (3) summary
    pfam03281
    Location:351479
    Mab-21; Mab-21 protein
    pfam06936
    Location:43112
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:1273
    DivIC; Septum formation initiator
  3. NM_033397.3NP_203755.1  inositol 1,4,5-trisphosphate receptor-interacting protein precursor

    See identical proteins and their annotated locations for NP_203755.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA085530, AB051541, AK094802, BC070108, BG007055, BQ014093, CA446720, DA832442, DR763519, EL593529
    Consensus CDS
    CCDS7557.1
    UniProtKB/Swiss-Prot
    Q8IWB1
    Related
    ENSP00000278071.2, ENST00000278071.6
    Conserved Domains (3) summary
    pfam03281
    Location:351479
    Mab-21; Mab-21 protein
    pfam06936
    Location:43112
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:1273
    DivIC; Septum formation initiator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    104309696..104338465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270257.3XP_005270314.1  inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1

    Conserved Domains (3) summary
    pfam03281
    Location:356484
    Mab-21; Mab-21 protein
    pfam06936
    Location:48117
    Selenoprotein_S; Selenoprotein S (SelS)
    cl11433
    Location:1778
    DivIC; Septum formation initiator
Support Center