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FAA1 long-chain fatty acid-CoA ligase FAA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854495, updated on 29-Jun-2024

Summary

Gene symbol
FAA1
Gene description
long-chain fatty acid-CoA ligase FAA1
Primary source
FungiDB:YOR317W
Locus tag
YOR317W
See related
SGD:S000005844; AllianceGenome:SGD:S000005844; VEuPathDB:YOR317W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables long-chain fatty acid-CoA ligase activity and medium-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid import into cell; long-chain fatty-acyl-CoA metabolic process; and sphingoid long-chain base transport. Located in lipid droplet and plasma membrane. Used to study Sjogren-Larsson syndrome. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to several human genes including ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See FAA1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (909343..911445)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene metal cation transporter COT1 Neighboring gene uncharacterized protein Neighboring gene U2 snRNP complex subunit HSH49 Neighboring gene glucose N-acetyltransferase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid-CoA ligase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables medium-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
long-chain fatty acid-CoA ligase FAA1
NP_014962.3
  • Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; accounts for most acyl-CoA synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    909343..911445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183737.3NP_014962.3  TPA: long-chain fatty acid-CoA ligase FAA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014962.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W316, P30624
    UniProtKB/TrEMBL
    A0A8H4BV89, A6ZPF1, B3LJY1, B5VSJ2, C7GNU5, C8ZH68, G2WNI3, N1NYY1
    Conserved Domains (2) summary
    cd17639
    Location:95685
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
    cl17068
    Location:217281
    AFD_class_I; Adenylate forming domain, Class I superfamily