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COT1 metal cation transporter COT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854494, updated on 24-Jan-2026
Official Symbol
COT1
Official Full Name
metal cation transporter COT1
Primary source
SGD:S000005843
Locus tag
YOR316C
See related
AllianceGenome:SGD:S000005843; FungiDB:YOR316C; VEuPathDB:YOR316C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cobalt ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Involved in cobalt ion transport; intracellular zinc ion homeostasis; and zinc ion transport. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to several human genes including SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See COT1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (906236..907555, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sfg1p Neighboring gene uncharacterized protein Neighboring gene long-chain fatty acid-CoA ligase FAA1

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Conklin DS, et al. Mol Cell Biol, 1992 Sep. PMID 1508175, Free PMC Article
  2. The Genome Sequence of the Jean-Talon Strain, an Archeological Beer Yeast from Québec, Reveals Traces of Adaptation to Specific Brewing Conditions. Fijarczyk A, et al. G3 (Bethesda), 2020 Sep 2. PMID 32605927, Free PMC Article
  3. Biochemical properties of vacuolar zinc transport systems of Saccharomyces cerevisiae. MacDiarmid CW, et al. J Biol Chem, 2002 Oct 18. PMID 12161436
  4. The plant CDF family member TgMTP1 from the Ni/Zn hyperaccumulator Thlaspi goesingense acts to enhance efflux of Zn at the plasma membrane when expressed in Saccharomyces cerevisiae. Kim D, et al. Plant J, 2004 Jul. PMID 15225288
  5. Two genes encoding Arabidopsis halleri MTP1 metal transport proteins co-segregate with zinc tolerance and account for high MTP1 transcript levels. Dräger DB, et al. Plant J, 2004 Aug. PMID 15255871

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zrc1 and Cot1 vacuolar zinc transporters control alkaline phosphatase accumulation and activity.
    Title: Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae.
  2. analysis of how one single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity
    Title: A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cobalt ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cobalt ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inorganic ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular monoatomic cation homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
metal cation transporter COT1
NP_014961.3
  • Vacuolar transporter that mediates zinc transport into vacuole; overexpression confers resistance to cobalt and rhodium; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    906236..907555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183736.3 → NP_014961.3  metal cation transporter COT1

    See identical proteins and their annotated locations for NP_014961.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W314, P32798
    UniProtKB/TrEMBL
    A0A0L8VGU6, B5VSJ1, C7GNU7, N1NXG6
    Conserved Domains (1) summary
    COG1230
    Location:9 → 384
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32798.2

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