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KIAA1755 KIAA1755 [ Homo sapiens (human) ]

Gene ID: 85449, updated on 3-Mar-2026
Official Symbol
KIAA1755provided by HGNC
Official Full Name
KIAA1755provided by HGNC
Primary source
HGNC:HGNC:29372
See related
Ensembl:ENSG00000149633 AllianceGenome:HGNC:29372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
quo
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Predicted to be active in cytoplasm and plasma membrane. Predicted to be extrinsic component of membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in brain (RPKM 4.2), gall bladder (RPKM 3.0) and 20 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See KIAA1755 in Genome Data Viewer
Location:
20q11.23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (38210503..38260735, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (39936620..39986885, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36838905..36889137, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904899 Neighboring gene Sharpr-MPRA regulatory region 2618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:36740455-36740954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36770637-36771306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36771307-36771975 Neighboring gene transglutaminase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12897 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:36845917-36847116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36847531-36848032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36874844-36875344 Neighboring gene uncharacterized LOC124904900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36881371-36881963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36888895-36889394 Neighboring gene uncharacterized LOC149684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36915021-36915522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36926779-36927294 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:36962737-36963936 Neighboring gene bactericidal permeability increasing protein Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36970603-36971380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36972161-36972938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36982312-36982872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36982873-36983432 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:36986777-36987278 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:36991245-36991414 Neighboring gene lipopolysaccharide binding protein

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics. Yazdani A, et al. BMC Genomics, 2019 May 21. PMID 31113383, Free PMC Article
  2. Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula. Daggett DF, et al. Curr Biol, 2004 Sep 21. PMID 15380064
  3. Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. von der Heyde B, et al. Sci Rep, 2020 Jul 16. PMID 32678143, Free PMC Article
  4. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. den Hoed M, et al. Nat Genet, 2013 Jun. PMID 23583979, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Dec 31. PMID 11214970

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
uncharacterized protein KIAA1755
Names
RP5-1054A22.3
quattro homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053038.1 RefSeqGene

    Range
    5038..55270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029864.2 → NP_001025035.1  uncharacterized protein KIAA1755 isoform a

    See identical proteins and their annotated locations for NP_001025035.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL031651
    Consensus CDS
    CCDS33467.1
    UniProtKB/Swiss-Prot
    Q5JYT7, Q9C0A8
    Related
    ENSP00000279024.4, ENST00000279024.9
    Conserved Domains (1) summary
    pfam15450
    Location:675 → 1043
    CCDC154; Coiled-coil domain-containing protein 154

  2. NM_001348708.2 → NP_001335637.1  uncharacterized protein KIAA1755 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL031651
    Related
    ENSP00000574266.1, ENST00000904207.1

RNA

  1. NR_145960.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL031651

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    38210503..38260735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452013.2 → XP_024307781.1  uncharacterized protein KIAA1755 isoform X8

    Related
    ENSP00000574270.1, ENST00000904211.1
    Conserved Domains (1) summary
    pfam15450
    Location:328 → 679
    CCDC154; Coiled-coil domain-containing protein 154

  2. XM_024452012.2 → XP_024307780.1  uncharacterized protein KIAA1755 isoform X6

    Related
    ENSP00000574262.1, ENST00000904203.1
    Conserved Domains (1) summary
    pfam15450
    Location:394 → 745
    CCDC154; Coiled-coil domain-containing protein 154

  3. XM_024452008.2 → XP_024307776.1  uncharacterized protein KIAA1755 isoform X1

    Related
    ENSP00000574261.1, ENST00000904202.1
    Conserved Domains (1) summary
    pfam15450
    Location:662 → 1030
    CCDC154; Coiled-coil domain-containing protein 154

  4. XM_024452010.2 → XP_024307778.1  uncharacterized protein KIAA1755 isoform X3

    Related
    ENSP00000574264.1, ENST00000904205.1

  5. XM_024452009.2 → XP_024307777.1  uncharacterized protein KIAA1755 isoform X2

    Related
    ENSP00000631957.1, ENST00000961898.1

  6. XM_047440570.1 → XP_047296526.1  uncharacterized protein KIAA1755 isoform X5

  7. XM_024452011.2 → XP_024307779.1  uncharacterized protein KIAA1755 isoform X4

  8. XM_047440575.1 → XP_047296531.1  uncharacterized protein KIAA1755 isoform X12

    UniProtKB/TrEMBL
    A0A087X0C1

  9. XM_047440572.1 → XP_047296528.1  uncharacterized protein KIAA1755 isoform X9

    UniProtKB/TrEMBL
    A0A087X0C1

  10. XM_047440571.1 → XP_047296527.1  uncharacterized protein KIAA1755 isoform X7

    UniProtKB/TrEMBL
    A0A087X0C1

  11. XM_047440574.1 → XP_047296530.1  uncharacterized protein KIAA1755 isoform X11

    UniProtKB/TrEMBL
    A0A087X0C1

  12. XM_047440573.1 → XP_047296529.1  uncharacterized protein KIAA1755 isoform X10

    UniProtKB/TrEMBL
    A0A087X0C1

  13. XM_024452015.2 → XP_024307783.1  uncharacterized protein KIAA1755 isoform X14

    UniProtKB/TrEMBL
    A0A087X0C1
    Related
    ENSP00000483264.1, ENST00000496900.2

  14. XM_024452014.2 → XP_024307782.1  uncharacterized protein KIAA1755 isoform X13

    UniProtKB/TrEMBL
    A0A087X0C1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    39936620..39986885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324184.1 → XP_054180159.1  uncharacterized protein KIAA1755 isoform X8

  2. XM_054324182.1 → XP_054180157.1  uncharacterized protein KIAA1755 isoform X6

  3. XM_054324177.1 → XP_054180152.1  uncharacterized protein KIAA1755 isoform X1

  4. XM_054324179.1 → XP_054180154.1  uncharacterized protein KIAA1755 isoform X3

  5. XM_054324178.1 → XP_054180153.1  uncharacterized protein KIAA1755 isoform X2

  6. XM_054324181.1 → XP_054180156.1  uncharacterized protein KIAA1755 isoform X5

  7. XM_054324180.1 → XP_054180155.1  uncharacterized protein KIAA1755 isoform X4

  8. XM_054324188.1 → XP_054180163.1  uncharacterized protein KIAA1755 isoform X12

    UniProtKB/TrEMBL
    A0A087X0C1

  9. XM_054324185.1 → XP_054180160.1  uncharacterized protein KIAA1755 isoform X9

    UniProtKB/TrEMBL
    A0A087X0C1

  10. XM_054324183.1 → XP_054180158.1  uncharacterized protein KIAA1755 isoform X7

    UniProtKB/TrEMBL
    A0A087X0C1

  11. XM_054324187.1 → XP_054180162.1  uncharacterized protein KIAA1755 isoform X11

    UniProtKB/TrEMBL
    A0A087X0C1

  12. XM_054324186.1 → XP_054180161.1  uncharacterized protein KIAA1755 isoform X10

    UniProtKB/TrEMBL
    A0A087X0C1

  13. XM_054324190.1 → XP_054180165.1  uncharacterized protein KIAA1755 isoform X14

    UniProtKB/TrEMBL
    A0A087X0C1

  14. XM_054324189.1 → XP_054180164.1  uncharacterized protein KIAA1755 isoform X13

    UniProtKB/TrEMBL
    A0A087X0C1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JYT7.2 GenPept UniProtKB/Swiss-Prot:Q5JYT7

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