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RRS1 ribosome biogenesis protein RRS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854469, updated on 10-May-2026
Official Symbol
RRS1
Official Full Name
ribosome biogenesis protein RRS1
Primary source
SGD:S000005820
Locus tag
YOR294W
See related
AllianceGenome:SGD:S000005820; FungiDB:YOR294W; VEuPathDB:YOR294W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis; and ribosomal large subunit export from nucleus. Located in nuclear periphery; nucleolus; and nucleoplasm. Part of preribosome, large subunit precursor. Used to study Huntington's disease and papillary thyroid carcinoma. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See RRS1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (868340..868951)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein eS10 RPS10A Neighboring gene uncharacterized protein Neighboring gene Uaf30p Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae. Miyoshi K, et al. FEBS Lett, 2004 May 7. PMID 15135061
  2. Chaperoning 5S RNA assembly. Madru C, et al. Genes Dev, 2015 Jul 1. PMID 26159998, Free PMC Article
  3. Genetic interaction between ribosome biogenesis and inositol polyphosphate metabolism in Saccharomyces cerevisiae. Horigome C, et al. Biosci Biotechnol Biochem, 2009 Feb. PMID 19202276
  4. RRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae. Tsuno A, et al. Mol Cell Biol, 2000 Mar. PMID 10688653, Free PMC Article
  5. Ebp2p, yeast homologue of a human protein that interacts with Epstein-Barr virus nuclear antigen 1, is required for pre-rRNA processing and ribosomal subunit assembly. Tsujii R, et al. Genes Cells, 2000 Jul. PMID 10947841

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of Cgr1 results in inhibition of 5S ribonucleoprotein(RNP) rotation, but suppressor mutations mapping in factors Rpf2, Rrs1, and Rpl5, stabilizing the pre-rotational stage of the 5S RNP, partly overcome this defect.
    Title: Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.
  2. These results suggest that the ribosome biogenesis factors Ebp2 and Rrs1 cooperate with Mps3 to mediate telomere clustering, but not telomere tethering, by binding Sir4.
    Title: Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.
  3. identified a ribonucleoprotein neighborhood in preribosomes that contains two ribosome assembly factors, Rpf2 and Rrs1, two ribosomal proteins, rpL5 and rpL11, and 5S rRNA
    Title: Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes.
  4. Rrs1p has a role in coordinating the assembly of L5-5S rRNA on 60S ribosomal subunits.
    Title: Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3'-extension of 5S rRNA in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor HDA PubMed 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
ribosome biogenesis protein RRS1
NP_014937.1
  • Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    868340..868951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183713.1 → NP_014937.1  ribosome biogenesis protein RRS1

    See identical proteins and their annotated locations for NP_014937.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2Z3, Q08746
    UniProtKB/TrEMBL
    A6ZPC9, B3LJV9, B5VSH2, C7GNW7, C8ZH44, G2WNG0, N1NWX7
    Conserved Domains (1) summary
    COG5225
    Location:9 → 203
    RRS1; Uncharacterized protein involved in ribosome biogenesis [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08746.1

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