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RRS1 Rrs1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854469, updated on 18-Jan-2023

Summary

Gene symbol
RRS1
Gene description
Rrs1p
Primary source
SGD:S000005820
Locus tag
YOR294W
See related
AllianceGenome:SGD:S000005820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis; and ribosomal large subunit export from nucleus. Located in nuclear periphery; nucleolus; and nucleoplasm. Part of preribosome, large subunit precursor. Used to study Huntington's disease and thyroid gland papillary carcinoma. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See RRS1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (868340..868951)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S10A Neighboring gene uncharacterized protein Neighboring gene Uaf30p Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the RRS1 gene: The RRS1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, large subunit precursor HDA PubMed 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Rrs1p
NP_014937.1
  • Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    868340..868951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183713.1NP_014937.1  TPA: Rrs1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014937.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2Z3, Q08746
    UniProtKB/TrEMBL
    A0A6A5Q4U5, A0A6C1E252, A6ZPC9, B3LJV9, C7GNW7, G2WNG0, H0GNZ7, N1NWX7
    Conserved Domains (1) summary
    COG5225
    Location:9203
    RRS1; Uncharacterized protein involved in ribosome biogenesis [Translation, ribosomal structure and biogenesis]