PAC1 Pac1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: PAC1
Gene description: Pac1p
Primary source: SGD:S000005795
Locus tag: YOR269W
Gene type: protein coding
RNA name: Pac1p
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

these findings indicate that dynein activity is directly switched "on" by Num1, which induces Pac1/LIS1 removal.
Title: The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition.
Lis1 (Pac1) regulates dynein by sterically blocking its mechanochemical cycle.
Title: Lis1 regulates dynein by sterically blocking its mechanochemical cycle.
Here we show that two MAPs-the CLIP-170 homologue Bik1p and the Lis1 homologue Pac1p-interact with several proteins in the sumoylation pathway
Title: The yeast homologue of the microtubule-associated protein Lis1 interacts with the sumoylation machinery and a SUMO-targeted ubiquitin ligase.

Submit: New GeneRIF Correction

Ether lipid metabolism, organism-specific biosystem (from KEGG)
Ether lipid metabolism, organism-specific biosystem
Ether lipid metabolism
Ether lipid metabolism, conserved biosystem (from KEGG)
Ether lipid metabolism, conserved biosystem
Ether lipid metabolism
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Homologs of the PAC1 gene: The PAC1 gene is conserved in S.cerevisiae, K.lactis, and E.gossypii.
The Hierarchical Catalog of Orthologs

Function	Evidence Code	Pubs
dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
microtubule organizing center organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
regulation of microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	HDA more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
kinetochore	IBA Inferred from Biological aspect of Ancestor more info	PubMed
microtubule	IEA Inferred from Electronic Annotation more info
microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
spindle pole	IEA Inferred from Electronic Annotation more info

NP_014912.1

Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly

The following sections contain reference sequences that belong to a specific genome build. Explain