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RBL2 Rbl2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854439, updated on 23-Apr-2026
Official Symbol
RBL2
Official Full Name
Rbl2p
Primary source
SGD:S000005791
Locus tag
YOR265W
See related
AllianceGenome:SGD:S000005791; FungiDB:YOR265W; VEuPathDB:YOR265W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables beta-tubulin binding activity. Involved in tubulin complex assembly. Located in cytoplasm. Orthologous to human TBCA (tubulin folding cofactor A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RBL2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (820454..820774)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene GTPase GPN2 Neighboring gene Dse3p Neighboring gene Pnt1p Neighboring gene putative serine/threonine protein kinase HRK1

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of the post-chaperonin beta-tubulin binding cofactor Rbl2p. Steinbacher S. Nat Struct Biol, 1999 Nov. PMID 10542094
  2. Rbl2p, a yeast protein that binds to beta-tubulin and participates in microtubule function in vivo. Archer JE, et al. Cell, 1995 Aug 11. PMID 7634332
  3. Model for the yeast cofactor A-beta-tubulin complex based on computational docking and mutagensis. You L, et al. J Mol Biol, 2004 Aug 27. PMID 15321725
  4. Formation and function of the Rbl2p-beta-tubulin complex. Archer JE, et al. Mol Cell Biol, 1998 Mar. PMID 9488492, Free PMC Article
  5. Regulation of tubulin polypeptides and microtubule function: Luv1p [correction of Rki1p] interacts with the beta-tubulin binding protein Rbl2p. Smith AM, et al. Chromosoma, 1998 Dec. PMID 9914379

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-tubulin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Rbl2p
NP_014908.1
  • Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    820454..820774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183684.1 → NP_014908.1  Rbl2p

    See identical proteins and their annotated locations for NP_014908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2W5, P48606
    UniProtKB/TrEMBL
    A6ZPA2, B3LJT2, C7GWC5, C8ZH16, G2WND2, N1NWW1
    Conserved Domains (1) summary
    pfam02970
    Location:6 → 92
    TBCA; Tubulin binding cofactor A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48606.1

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