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RPN8 proteasome regulatory particle lid subunit RPN8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854435, updated on 22-Sep-2022

Summary

Gene symbol
RPN8
Gene description
proteasome regulatory particle lid subunit RPN8
Primary source
SGD:S000005787
Locus tag
YOR261C
See related
AllianceGenome:SGD:S000005787
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable isopeptidase activity and metallopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD7 (proteasome 26S subunit, non-ATPase 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See RPN8 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (815915..816931, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPT4 Neighboring gene translation initiation factor eIF2B subunit gamma Neighboring gene putative GTPase GPN2 Neighboring gene Dse3p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the RPN8 gene: The RPN8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of proteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome regulatory particle IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome regulatory particle, lid subcomplex IDA
Inferred from Direct Assay
more info
PubMed 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome regulatory particle lid subunit RPN8
NP_014904.3
  • Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    815915..816931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183680.3NP_014904.3  TPA: proteasome regulatory particle lid subunit RPN8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014904.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q08723, Q6Q5I7
    UniProtKB/TrEMBL
    A0A8H4F7D8, N1P3K9
    Conserved Domains (1) summary
    cd08062
    Location:6303
    MPN_RPN7_8; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8