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HNT3 DNA 5'-adenosine monophosphate hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854432, updated on 24-Jan-2026
Official Symbol
HNT3
Official Full Name
DNA 5'-adenosine monophosphate hydrolase
Primary source
SGD:S000005784
Locus tag
YOR258W
See related
AllianceGenome:SGD:S000005784; FungiDB:YOR258W; VEuPathDB:YOR258W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA 5'-adenosine monophosphate hydrolase activity. Involved in DNA damage response. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 1 and olivopontocerebellar atrophy. Orthologous to human APTX (aprataxin). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (811671..812324)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative zinc metalloprotease Neighboring gene centrin Neighboring gene proteasome regulatory particle base subunit RPT4 Neighboring gene translation initiation factor eIF2B subunit gamma

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Tumbale P, et al. Nature, 2014 Feb 6. PMID 24362567, Free PMC Article
  2. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. Bieganowski P, et al. J Biol Chem, 2002 Mar 29. PMID 11805111, Free PMC Article
  3. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Ahel I, et al. Nature, 2006 Oct 12. PMID 16964241
  4. Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair. Daley JM, et al. DNA Repair (Amst), 2010 Jun 4. PMID 20399152, Free PMC Article
  5. Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability. Peng J, et al. Nucleic Acids Res, 2016 Dec 1. PMID 27536003, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA 5'-adenosine monophosphate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA 5'-adenosine monophosphate hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA 5'-adenosine monophosphate hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-3'-diphospho-5'-guanosine diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mismatched DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-strand break-containing DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in single strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA 5'-adenosine monophosphate hydrolase
NP_014901.1
  • DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    811671..812324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183677.1 → NP_014901.1  DNA 5'-adenosine monophosphate hydrolase

    See identical proteins and their annotated locations for NP_014901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2V9, Q05189, Q08702
    UniProtKB/TrEMBL
    B3LJS6, C7GWD1, C8ZH09, N1NYS3
    Conserved Domains (2) summary
    pfam01230
    Location:15 → 139
    HIT; HIT domain
    pfam16278
    Location:153 → 212
    zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08702.1

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