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KNDC1 kinase non-catalytic C-lobe domain containing 1 [ Homo sapiens (human) ]

Gene ID: 85442, updated on 23-Nov-2021

Summary

Official Symbol
KNDC1provided by HGNC
Official Full Name
kinase non-catalytic C-lobe domain containing 1provided by HGNC
Primary source
HGNC:HGNC:29374
See related
Ensembl:ENSG00000171798 MIM:616237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
v-KIND; RASGEF2; C10orf23; Very-KIND; bB439H18.3
Summary
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
Expression
Biased expression in brain (RPKM 6.5), ovary (RPKM 2.2) and 6 other tissues See more
Orthologs
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Genomic context

See KNDC1 in Genome Data Viewer
Location:
10q26.3
Exon count:
34
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (133160219..133226412)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134973723..135039916)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor A1 Neighboring gene CEB36 minisatellite repeat instability region Neighboring gene ribosomal protein L5 pseudogene 28 Neighboring gene uncharacterized LOC105378574 Neighboring gene uncharacterized LOC105378573 Neighboring gene undifferentiated embryonic cell transcription factor 1 Neighboring gene VENT homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cerebellar granule cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of guanyl-nucleotide exchange factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinase non-catalytic C-lobe domain-containing protein 1
Names
KIND domain-containing protein 1
RasGEF domain family, member 2
cerebral protein 9
kinase non-catalytic C-lobe domain (KIND) containing 1
protein very KIND
ras-GEF domain-containing family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053178.1 RefSeqGene

    Range
    5124..71317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001347864.2NP_001334793.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL445199
    Related
    ENSP00000507288.1, ENST00000684739.1
  2. NM_001347865.2NP_001334794.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL445199
    Related
    ENSP00000507020.1, ENST00000682765.1
  3. NM_001347866.2NP_001334795.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL445199
    Related
    ENSP00000506821.1, ENST00000683259.1
    Conserved Domains (1) summary
    cl21453
    Location:37120
    PKc_like; Protein Kinases, catalytic domain
  4. NM_152643.8NP_689856.6  kinase non-catalytic C-lobe domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_689856.6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL445199
    Consensus CDS
    CCDS7674.1
    UniProtKB/Swiss-Prot
    Q76NI1
    Related
    ENSP00000304437.3, ENST00000304613.8
    Conserved Domains (5) summary
    cd06224
    Location:12541368
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00750
    Location:37217
    KIND; kinase non-catalytic C-lobe domain
    pfam00617
    Location:14751673
    RasGEF; RasGEF domain
    pfam15760
    Location:215333
    DLEU7; Leukemia-associated protein 7
    cl21453
    Location:444608
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    133160219..133226412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016858.2XP_016872347.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd06224
    Location:12541368
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00750
    Location:37217
    KIND; kinase non-catalytic C-lobe domain
    PHA03247
    Location:619896
    PHA03247; large tegument protein UL36; Provisional
    pfam00617
    Location:14751560
    RasGEF; RasGEF domain
    cl21453
    Location:444608
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017016859.2XP_016872348.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform X2

    Related
    ENSP00000507504.1, ENST00000684081.1
    Conserved Domains (3) summary
    smart00750
    Location:37217
    KIND; kinase non-catalytic C-lobe domain
    PHA03247
    Location:619896
    PHA03247; large tegument protein UL36; Provisional
    cl21453
    Location:444608
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024448245.1XP_024304013.1  kinase non-catalytic C-lobe domain-containing protein 1 isoform X3

    Related
    ENSP00000506878.1, ENST00000478074.6
    Conserved Domains (1) summary
    cl21453
    Location:37132
    PKc_like; Protein Kinases, catalytic domain
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