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ABP140 tRNA(Thr) (cytosine(32)-N(3))-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854414, updated on 30-Jul-2025
Official Symbol
ABP140
Official Full Name
tRNA(Thr) (cytosine(32)-N(3))-methyltransferase
Primary source
SGD:S000005765
Locus tag
YOR239W
See related
AllianceGenome:SGD:S000005765; FungiDB:YOR239W; VEuPathDB:YOR239W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TRM140; YOR240W
Summary
Enables actin filament binding activity; protein-macromolecule adaptor activity; and tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Located in actin filament and actin filament bundle. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See ABP140 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (784857..786744)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein related protein HES1 Neighboring gene uncharacterized protein Neighboring gene tetrahydrofolate synthase Neighboring gene Ssp2p

Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. F-actin dynamics in Neurospora crassa. Berepiki A, et al. Eukaryot Cell, 2010 Apr. PMID 20139238, Free PMC Article
  2. Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chan CT, et al. Chem Res Toxicol, 2015 May 18. PMID 25772370, Free PMC Article
  3. Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae. Asakura T, et al. Oncogene, 1998 Jan 8. PMID 9467951
  4. Actin cable dynamics in budding yeast. Yang HC, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11805329, Free PMC Article
  5. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. D'Silva S, et al. RNA, 2011 Jun. PMID 21518804, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates.
    Title: S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates.
  2. a model of translational coupling was proposed, in which ABP140 mRNA is tethered to actin cables via its nascent protein product and is transported to the distal pole by actin retrograde flow. [review]
    Title: Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae.
  3. Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae
    Title: Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae.
  4. A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop
    Title: A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (cytidine-3-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (cytidine-3-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (cytidine-3-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in viral translational frameshifting IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament bundle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 
Preferred Names
tRNA(Thr) (cytosine(32)-N(3))-methyltransferase
NP_014882.4
  • AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    784857..786744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183658.6 → NP_014882.4  TPA: tRNA(Thr) (cytosine(32)-N(3))-methyltransferase

    See identical proteins and their annotated locations for NP_014882.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2U2, Q08641, Q08644
    UniProtKB/TrEMBL
    A6ZP79
    Conserved Domains (2) summary
    TIGR00927
    Location:53 → 247
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam08242
    Location:438 → 543
    Methyltransf_12; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08641.3

Gene LinkOut

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